Department of Internal Medicine, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.
Osteoarthritis Cartilage. 2013 Sep;21(9):1207-13. doi: 10.1016/j.joca.2013.05.001.
To describe the frequency of bone marrow lesions (BMLs) detected by magnetic resonance imaging (MRI), and to examine the association of BMLs with knee pain severity in community residents in Korea.
Participants were randomly chosen from the population-based Hallym Aging Study, irrespective of whether they had knee osteoarthritis (OA) or pain. Demographic and knee pain data were obtained by questionnaire. Radiographic evaluations consisted of weight-bearing knee anteroposterior radiographs and 1.5-T MRI scans. MRI was performed in the dominant knees of subjects without knee pain and in the more symptomatic knees of subjects with knee pain. BMLs were graded according to the whole-organ MRI score.
The mean age of the 358 study subjects was 71.8 years, and 34.5% of subjects had radiographically detected knee OA. The prevalences of BMLs and large BMLs in the tibiofemoral compartments were 80.3% and 40.4%, respectively. After adjusting for age, sex, and body mass index, total and medial compartment BML scores were significantly associated with the presence of knee pain, and the association was stronger as the summary score for BML increased. In proportional regression analysis, knee pain severity increased with BML severity in any compartment and in the medial compartment.
BMLs detected by MRI were highly prevalent in this elderly Asian population. BMLs were significantly linked to knee pain, and BML severity correlated with knee pain severity. BMLs may be important surrogate targets for monitoring pain and structure modification in OA therapeutics.
描述磁共振成像（MRI）检测到的骨髓病变（BML）的频率，并研究 BML 与韩国社区居民膝关节疼痛严重程度的关系。
参与者是从基于人群的 Hallym 衰老研究中随机选择的，无论他们是否患有膝关节骨关节炎（OA）或疼痛。通过问卷调查获得人口统计学和膝关节疼痛数据。放射学评估包括负重膝关节前后位 X 线片和 1.5-T MRI 扫描。在没有膝关节疼痛的受试者的优势膝关节和有膝关节疼痛的受试者的症状更严重的膝关节中进行 MRI。BML 根据全器官 MRI 评分进行分级。
358 名研究对象的平均年龄为 71.8 岁，34.5%的受试者有放射学上检测到的膝关节 OA。在胫股关节间室中，BML 和大 BML 的患病率分别为 80.3%和 40.4%。在校正年龄、性别和体重指数后，总 BML 评分和内侧间室 BML 评分与膝关节疼痛的存在显著相关，随着 BML 总分的增加，相关性更强。在比例回归分析中，任何间室和内侧间室的 BML 严重程度与膝关节疼痛严重程度呈正相关。
在这个老年亚洲人群中，通过 MRI 检测到的 BML 非常普遍。BML 与膝关节疼痛显著相关，BML 严重程度与膝关节疼痛严重程度相关。BML 可能是监测 OA 治疗中疼痛和结构改变的重要替代指标。
