Safdar Samreen M, Rehman Jalil U, Samman Eba M, Bahabri Nezar M
Department of Medicine, King Faisal Specialist Hospital, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2013 Aug;34(8):861-4.
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and potentially life-threatening condition characterized by uncontrolled hyper inflammation caused by various inherited or acquired immune deficiencies. We report a case of a 42-year-old man, newly diagnosed with HIV on the basis of a low CD4 T lymphocyte count (17/mm³) and HIV viral load >100,000 copies/mL by polymerase chain reaction tests who was undergoing an anti-retroviral regimen (emitricitabine, tenofovir disoproxil fumarate, ritonavir, and darunavir) and opportunistic infection prophylaxis (clarithromycin and atovaquone). He was concomitantly diagnosed with hemophagocytic syndrome, also known as HLH. He developed increasingly severe pancytopenia while on treatment with anti-retroviral drugs.
噬血细胞性淋巴组织细胞增生症（HLH）是一种侵袭性且可能危及生命的疾病，其特征是由各种遗传性或获得性免疫缺陷导致的不受控制的过度炎症。我们报告一例42岁男性病例，该患者基于低CD4 T淋巴细胞计数（17/mm³）和聚合酶链反应检测显示HIV病毒载量>100,000拷贝/mL，被新诊断为HIV，正在接受抗逆转录病毒治疗方案（恩曲他滨、替诺福韦酯富马酸盐、利托那韦和达芦那韦）以及机会性感染预防治疗（克拉霉素和阿托伐醌）。他同时被诊断为噬血细胞综合征，也称为HLH。在接受抗逆转录病毒药物治疗期间，他出现了日益严重的全血细胞减少症。
