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[芋螺毒素:从腹足纲动物的生物多样性到新型药物]

[Conotoxins: from the biodiversity of gastropods to new drugs].

作者信息

Fedosov A É, Moshkovskiĭ S A, Kuznetsova K G, Olivera B M

出版信息

Biomed Khim. 2013 May-Jun;59(3):267-94. doi: 10.18097/pbmc20135903267.

Abstract

A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970th. There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.

摘要

一篇综述描述了自20世纪70年代发现芋螺毒素(从芋螺属海洋腹足动物中分离出的肽类毒素)以来,该毒素的研究总体趋势。文中披露了芋螺毒素的分类、其结构多样性以及作用于其分子靶点(主要是离子通道)的不同方式。在芋螺毒素研究的应用方面,讨论了基于芋螺毒素结构的药物发现与开发。首个示例性药物是齐考诺肽,它是一种新一代镇痛药。

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