阿米巴痢疾
Amoebic dysentery.
作者信息
Marie Chelsea, Petri William Arthur
机构信息
Division of Infectious Diseases and Global Health, University of Virginia School of Medicine, Charlottesville, USA.
出版信息
BMJ Clin Evid. 2013 Aug 30;2013:0918.
INTRODUCTION
Amoebic dysentery is caused by the protozoan parasite Entamoeba histolytica. It is transmitted in areas where poor sanitation allows contamination of drinking water and food with faeces. In these areas, up to 40% of people with diarrhoea may have amoebic dysentery.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of drug treatments for amoebic dysentery in endemic areas? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found 6 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS
In this systematic review, we present information relating to the effectiveness and safety of the following interventions: diiodohydroxyquinoline (iodoquinol), diloxanide, emetine, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, and tinidazole.
引言
阿米巴痢疾由原生动物寄生虫溶组织内阿米巴引起。在卫生条件差导致饮用水和食物受粪便污染的地区会传播该病。在这些地区，腹泻患者中高达40%可能患有阿米巴痢疾。
方法与结果
我们进行了一项系统评价，旨在回答以下临床问题：在流行地区，药物治疗阿米巴痢疾的效果如何？我们检索了：截至2013年6月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆以及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品和医疗产品监管局（MHRA）等相关组织的危害警示。
结果
我们找到了6项符合我们纳入标准的系统评价、随机对照试验或观察性研究。我们对干预措施的证据质量进行了GRADE评估。
结论
在本系统评价中，我们提供了以下干预措施有效性和安全性的相关信息：双碘喹啉、地洛西胺、依米丁、甲硝唑、硝唑尼特、奥硝唑、巴龙霉素、塞克硝唑和替硝唑。
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