Department of Anatomy, Howard University College of Medicine, 520 W St., NW, Washington, DC.
Hippocampus. 2013 Dec;23(12):1476-83. doi: 10.1002/hipo.22200. Epub 2013 Sep 30.
Recent research has determined that newborn neurons in the dentate gyrus of the hippocampus of the macaque are frequently adjacent to astrocytes immunoreactive for fatty acid binding protein-7 (FABP7). To investigate if a similar relationship between FABP7-positive (FABP7+) astrocytes and proliferating cells exists in the rodent brain, sections of brains from juvenile rats were stained by immunohistochemistry to demonstrate newborn cells (antibody to Ki67 protein) and FABP7+ astrocytes. In rat brains, FABP7+ astrocytes were particularly abundant in the dentate gyrus of the hippocampus and were frequently close to dividing cells immunoreactive for Ki67 protein. FABP7+ astrocytes were also present in the olfactory bulbs, arcuate nucleus of the hypothalamus, and in the dorsal medulla subjacent to the area postrema, sites where more modest numbers of newborn neurons can also be found. These data suggest that regional accumulations of FABP7+ astrocytes may represent reservoirs of cells having the potential for neurogenesis. Because FABP7+ astrocytes are particularly abundant in the hippocampus, and since the gene for FABP7 has been linked to Alzheimer's disease, age-related changes in FABP7+ astrocytes (mitochondrial degeneration) may be relevant to age-associated disorders of the hippocampus.
最近的研究确定，在猕猴海马齿状回中的新生神经元经常与脂肪酸结合蛋白-7（FABP7）免疫反应性的星形胶质细胞相邻。为了研究在啮齿动物脑中是否存在 FABP7 阳性（FABP7+）星形胶质细胞与增殖细胞之间的类似关系，用免疫组织化学染色对幼年大鼠的脑组织切片进行了染色，以显示新生细胞（Ki67 蛋白抗体）和 FABP7+星形胶质细胞。在大鼠脑中，FABP7+星形胶质细胞在海马齿状回中特别丰富，并且经常靠近 Ki67 蛋白免疫反应性的分裂细胞。FABP7+星形胶质细胞也存在于嗅球、下丘脑弓状核以及靠近最后区的背髓，在这些部位也可以发现数量较少的新生神经元。这些数据表明，FABP7+星形胶质细胞的区域聚集可能代表具有神经发生潜力的细胞的储备库。由于 FABP7+星形胶质细胞在海马中特别丰富，并且 FABP7 的基因与阿尔茨海默病有关，因此 FABP7+星形胶质细胞（线粒体退化）的年龄相关变化可能与海马相关的年龄相关疾病有关。
