Araujo Bruna Formentão, Silva Lígia Inez, Meireles Anamaria, Rosa Camila Thieimi, Gioppo Nereida Mello da Rosa, Jorge Alex Sandro, Kunz Regina Inês, Ribeiro Lucinéia de Fátima Chasko, Brancalhão Rose Meire Costa, Bertolini Gladson Ricardo Flor
Laboratory of Injuries Study and Physical Therapy Resources of the State University of Western Paraná (UNIOESTE), Universitária Street, 2069 Jd. Universitário, P.O. Box 711, 85819-110 Cascavel, PR, Brazil.
ISRN Rheumatol. 2013 Aug 12;2013:341832. doi: 10.1155/2013/341832. eCollection 2013.
The effectiveness of low-level laser therapy (LLLT) in the presence of an infectious process has not been well elucidated. The aim of the study was to evaluate the effects of LLLT in an experimental model of septic arthritis. Methods. Twenty-one Wistar rats were divided as follows: control group, no bacteria; placebo group, bacteria were inoculated; Treated group, bacteria were injected and treatment with LLLTwas performed. To assess nociception, a von Frey digital analgesimeter was applied. Synovial fluid was streaked to analyze bacterial growth. The standard strain of S. aureus was inoculated in the right knee. LLLT was performed with 660 nm, 2 J/cm(2), over 10 days. After treatment, the knees were fixed and processed for morphological analysis by light microscopy. Results. It was found that nociception increases in the right knee. There was a lack of results for the seeding of the synovial fluid. The morphological analysis showed slight recovery areas in the articular cartilage and synovia; however, there was the maintenance of the inflammatory infiltrate. Conclusion. The parameters used were not effective in the nociception reduction, even with the slight tissue recovery due to the maintenance of inflammatory infiltrate, but produced no change in the natural history of resolution of the infectious process.
低强度激光疗法（LLLT）在感染过程中的有效性尚未得到充分阐明。本研究的目的是评估LLLT在脓毒性关节炎实验模型中的效果。方法。将21只Wistar大鼠分为以下几组：对照组，无细菌感染；安慰剂组，接种细菌；治疗组，注射细菌并进行LLLT治疗。为评估痛觉，使用了von Frey数字镇痛仪。取滑膜液进行细菌生长分析。将金黄色葡萄球菌标准菌株接种于右膝。采用660 nm、2 J/cm²的参数进行LLLT治疗，持续10天。治疗后，固定膝关节并通过光学显微镜进行形态学分析。结果。发现右膝痛觉增加。滑膜液接种结果不理想。形态学分析显示关节软骨和滑膜有轻微恢复区域；然而，炎症浸润持续存在。结论。所使用的参数在减轻痛觉方面无效，尽管由于炎症浸润持续存在导致组织有轻微恢复，但在感染过程的自然转归方面未产生变化。
