部分容积效应校正 F-18 FDG PET/CT 对预测甲状腺癌患者转移淋巴结 131I 摄取的价值。

Usefulness of partial volume effect-corrected F-18 FDG PET/CT for predicting I-131 accumulation in the metastatic lymph nodes of patients with thyroid carcinoma.

机构信息

Departments of Clinical Radiology, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Fukuoka, Japan.

出版信息

Ann Nucl Med. 2013 Dec;27(10):873-9. doi: 10.1007/s12149-013-0767-8. Epub 2013 Sep 4.

DOI:10.1007/s12149-013-0767-8

PMID:24002992

Abstract

PURPOSE

The purpose of this study was to evaluate the clinical usefulness of partial volume effect (PVE)-corrected F-18 FDG PET/CT for predicting I-131 accumulation in metastatic lymph nodes (mLNs) during I-131 therapy for papillary thyroid carcinoma (PTC).

METHODS

Sixty-five mLNs in 31 PTC patients who underwent F-18 FDG PET/CT in an initial radioiodine therapy (RIT) were retrospectively evaluated. Of these, 25 mLNs were I-131-positive and 40 were I-131-negative. SUVmax and SUVmax with PVE correction (cSUVmax) were measured for each mLN, where PVE correction was performed utilizing a simple table lookup correction method. Then, SUVmax/cSUVmax was compared between I-131-positive and I-131-negative mLNs, including the analyses for the mLNs with small-sized (<1 cm) and weak FDG accumulation (SUVmax <3.5). The predictability for I-131 accumulation with SUVmax/cSUVmax was also compared.

RESULTS

For all 65 mLNs, SUVmax/cSUVmax was significantly higher in I-131-negative than I-131-positive mLNs (p < 0.0001). Only in cSUVmax, I-131-negative mLNs were significantly higher than I-131-positive, in terms of the 30 small-sized mLNs (p = 0.0001) and 14 mLNs with weak FDG uptake (p = 0.007). The highest accuracy in predictability for I-131 accumulation was significantly better with cSUVmax (92 %) than SUVmax (62 %) (p < 0.0001).

CONCLUSION

PVE-corrected F-18 FDG PET/CT is a valuable predictor of I-131 accumulation in mLNs during RIT.

摘要

目的

本研究旨在评估部分容积效应（PVE）校正的 F-18 FDG PET/CT 预测甲状腺乳头状癌（PTC）患者 I-131 治疗期间转移淋巴结（mLN）I-131 摄取的临床应用价值。

方法

回顾性分析 31 例 PTC 患者初始碘-131 治疗（RIT）期间行 F-18 FDG PET/CT 检查的 65 个 mLN。其中 25 个 mLN 为 I-131 阳性，40 个 mLN 为 I-131 阴性。测量每个 mLN 的最大标准摄取值（SUVmax）和经 PVE 校正后的最大标准摄取值（cSUVmax），采用简单的表格查找校正方法进行 PVE 校正。比较 I-131 阳性和 I-131 阴性 mLN 的 SUVmax/cSUVmax，并对 SUVmax<3.5、体积较小（<1cm）的 mLN 进行分析。比较 SUVmax/cSUVmax 对 I-131 摄取的预测能力。

结果

对于所有 65 个 mLN，I-131 阴性 mLN 的 SUVmax/cSUVmax 明显高于 I-131 阳性 mLN（p<0.0001）。仅在 cSUVmax 方面，30 个小体积 mLN（p=0.0001）和 14 个 FDG 摄取较弱的 mLN（p=0.007）中，I-131 阴性 mLN 明显高于 I-131 阳性 mLN。cSUVmax 对 I-131 摄取的预测准确性最高，明显优于 SUVmax（92%比 62%，p<0.0001）。