Heo Yujin, Jung Hyunwoo, Shin Sehyun
School of Mechanical Engineering, Korea University, Seoul, Korea.
Department of New Materials, SUNY at Stony Brook, NY, USA.
Clin Hemorheol Microcirc. 2015;59(3):211-8. doi: 10.3233/CH-131761.
Red blood cell (RBC) deformability is greatly affected by the osmolality, and maximum deformability, which is determined as maximal elongation index (EI(max)), is usually observed in isotonic conditions at high shear stresses (>20 Pa). Therefore, we examined osmotic RBC deformability over a range of shear stresses (0.5-20 Pa). We found that the RBC deformability at low shear stresses (1-3 Pa) was maximum in hypotonic conditions (225-250 mOsm/kg H2O), which is slightly lower than the normal range of osmolality in plasma (290-310 mOsm/kg H2O). The phenomenon that O(max) (the osmolality at EI(max)) is dependent on applied shear stress could play an important role in microcirculation in which osmolality varies widely.
红细胞（RBC）的变形能力受渗透压的影响很大，最大变形能力由最大伸长指数（EI(max)）确定，通常在高剪切应力（>20 Pa）的等渗条件下观察到。因此，我们研究了一系列剪切应力（0.5 - 20 Pa）下的红细胞渗透变形能力。我们发现，在低剪切应力（1 - 3 Pa）下，红细胞变形能力在低渗条件（225 - 250 mOsm/kg H2O）下最大，该渗透压略低于血浆渗透压的正常范围（290 - 310 mOsm/kg H2O）。O(max)（EI(max)时的渗透压）依赖于所施加的剪切应力这一现象，可能在渗透压变化很大的微循环中起重要作用。
Zotero 插件