Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Japan; Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Eur J Radiol. 2013 Nov;82(11):2018-27. doi: 10.1016/j.ejrad.2013.07.016. Epub 2013 Sep 5.
The purpose of this study was to compare diagnostic capabilities for assessment of recurrence in non-small cell lung cancer (NSCLC) patients by contrast-enhanced whole-body MRI (CE-WB-MRI) with and without CE-Quick 3D and double RF fat suppression technique (DFS), FDG-PET/CT and conventional radiological examinations.
A total of 134 pathologically proven and completely resected NSCLC patients (78 males, 56 females; mean age: 72 years) underwent FDG-PET/CT, CE-WB-MRI with and without Quick 3D and DFS at 3T as well as conventional radiological examinations. The probability of recurrence was assessed with a 5-point scoring system on a per-patient basis, and final diagnosis was made by consensus between two readers. The capability for overall recurrence assessment by all the methods was compared by means of ROC analysis and their sensitivity, specificity and accuracy by means of McNemar's test.
Although areas under the curve did not show any significant differences, specificity (100%) and accuracy (95.5%) of CE-WB-MRI with CE-Quick 3D and DFS were significantly higher than those of FDG-PET/CT (specificity: 93.6%, p=0.02; accuracy: 89.6%, p=0.01) and conventional radiological examinations (specificity: 92.7%, p=0.01; accuracy: 91.0%, p=0.03). In addition, specificity of CE-WB-MRI without CE-Quick 3D and DFS (100%) was significantly higher than that of FDG-PET/CT (p=0.02) and conventional radiological examinations (p=0.01).
Specificity and accuracy of CE-WB-MRI with CE-Quick 3D and DFS for assessment of recurrence in NSCLC patients are at least as high as, or higher than those of others.
本研究旨在比较对比增强全身磁共振成像（CE-WB-MRI）联合 CE-Quick 3D 和双射频脂肪抑制技术（DFS）、FDG-PET/CT 和常规影像学检查对非小细胞肺癌（NSCLC）患者复发评估的诊断能力。
共纳入 134 例经病理证实且完全切除的 NSCLC 患者（78 例男性，56 例女性；平均年龄：72 岁），在 3T 磁共振扫描仪上分别进行 FDG-PET/CT、CE-WB-MRI 联合或不联合 Quick 3D 和 DFS 以及常规影像学检查。每位患者采用 5 分制评分系统评估复发概率，由两位读者共同协商得出最终诊断。通过 ROC 分析比较所有方法对整体复发评估的能力，并通过 McNemar 检验比较其敏感性、特异性和准确性。
尽管曲线下面积无显著差异，但 CE-WB-MRI 联合 CE-Quick 3D 和 DFS 的特异性（100%）和准确性（95.5%）明显高于 FDG-PET/CT（特异性：93.6%，p=0.02；准确性：89.6%，p=0.01）和常规影像学检查（特异性：92.7%，p=0.01；准确性：91.0%，p=0.03）。此外，CE-WB-MRI 不联合 CE-Quick 3D 和 DFS 的特异性（100%）明显高于 FDG-PET/CT（p=0.02）和常规影像学检查（p=0.01）。
CE-WB-MRI 联合 CE-Quick 3D 和 DFS 对 NSCLC 患者复发评估的特异性和准确性至少与其他方法相当，或更高。
