高表达的 TMPRSS4 是宫颈鳞癌预后不良的预测因子。
High TMPRSS4 expression is a predictor of poor prognosis in cervical squamous cell carcinoma.
机构信息
Department of Transfusion, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, PR China.
出版信息
Cancer Epidemiol. 2013 Dec;37(6):993-7. doi: 10.1016/j.canep.2013.08.009. Epub 2013 Sep 6.
OBJECTIVE
The aim of this study was to clarify the clinical role of TMPRSS4 expression in cervical squamous cell carcinoma (CSCC) and to investigate the role of TMPRSS4 in predicting outcomes of patients with CSCC.
METHODS
The retrospective study enrolled 87 patients diagnosed with CSCC between 2004 and 2006. TMPRSS4 expression in CSCC was assessed by immunohistochemistry, and data on clinical variables were collected by retrospective chart review. The impact of TMPRSS4 expression on 5-year disease-free survival (DFS) and 5-year overall survival (OS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modeling.
RESULTS
The high expression of TMPRSS4 was 63.2% in 87 patients with CSCC, and 17.5% in 40 patients with benign cervical disease (P<0.001). High TMPRSS4 expression was significantly associated with tumor grade (P=0.005), lymph node metastasis (P=0.004), and deep cervical stromal invasion (P=0.025). Patients with high expression of TMPRSS4 had shorter OS and DFS than those with low expression (P=0.0205 and P=0.0318, respectively). In multivariate Cox regression analysis, high expression of TMPRSS4 was a potential prognostic indicator for OS (P=0.041) and DFS (P=0.015).
CONCLUSION
Our findings suggest that TMPRSS4 might play an important role in the progression of CSCC. TMPRSS4 could be a potential prognostic marker of CSCC.
目的
本研究旨在阐明 TMPRSS4 表达在宫颈鳞状细胞癌（CSCC）中的临床作用，并探讨 TMPRSS4 在预测 CSCC 患者结局中的作用。
方法
这项回顾性研究纳入了 2004 年至 2006 年间诊断为 CSCC 的 87 例患者。采用免疫组织化学法检测 CSCC 中的 TMPRSS4 表达，并通过回顾性病历回顾收集临床变量数据。通过 Kaplan-Meier 分析和 Cox 比例风险模型评估 TMPRSS4 表达对 5 年无病生存率（DFS）和 5 年总生存率（OS）的影响。
结果
在 87 例 CSCC 患者中，TMPRSS4 的高表达率为 63.2%，而在 40 例良性宫颈疾病患者中为 17.5%（P<0.001）。高 TMPRSS4 表达与肿瘤分级（P=0.005）、淋巴结转移（P=0.004）和深部宫颈间质浸润（P=0.025）显著相关。TMPRSS4 高表达患者的 OS 和 DFS 均短于 TMPRSS4 低表达患者（P=0.0205 和 P=0.0318）。多因素 Cox 回归分析显示，TMPRSS4 高表达是 OS（P=0.041）和 DFS（P=0.015）的潜在预后指标。
结论
我们的研究结果表明，TMPRSS4 可能在 CSCC 的进展中发挥重要作用。TMPRSS4 可能是 CSCC 的潜在预后标志物。
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