Laboratory of Molecular Microbiology, Slovak Tropical Institute, St. Elisabeth University College of Health and Social Sciences, Bratislava, Slovakia; Department of Laboratory Medicine, School of Health care and Social Work, Trnava University in Trnava, Trnava, Slovakia.
Trop Med Int Health. 2013 Oct;18(10):1267-8. doi: 10.1111/tmi.12178.
To determine patterns of nasopharyngeal colonisation in HIV-positive children.
Nasopharyngeal, nasal and ear swabs were prospectively taken from all children living in two paediatric nursing homes for HIV-positive orphans in Cambodia from 2004 to 2011.
A total of 882 swabs were taken, of which 586 tested positive for bacteria. Staphylococcus aureus was the most frequently isolated species (178 isolates; 30.4%) followed by Streptococcus pneumoniae (103 isolates; 17.6%) and Klebsiella pneumoniae (99 isolates; 16.9%). The rate of S. pneumoniae decreased in 2009 when a vaccination programme was introduced.
The respiratory tract of HIV-positive children receiving highly active antiretroviral therapy is commonly colonised by S. aureus and S. pneumoniae, while other species normally found in the respiratory tract, such as Moraxella catarrhalis, are far less frequent.
确定 HIV 阳性儿童鼻咽部定植模式。
2004 年至 2011 年，连续从柬埔寨两家儿科疗养院中生活的所有 HIV 阳性孤儿中前瞻性采集鼻咽部、鼻腔和耳部拭子。
共采集了 882 份拭子，其中 586 份检测出细菌阳性。金黄色葡萄球菌是最常分离的物种（178 株；30.4%），其次是肺炎链球菌（103 株；17.6%）和肺炎克雷伯菌（99 株；16.9%）。2009 年引入疫苗接种计划后，肺炎链球菌的发生率下降。
接受高效抗逆转录病毒治疗的 HIV 阳性儿童的呼吸道常被金黄色葡萄球菌和肺炎链球菌定植，而其他通常存在于呼吸道的物种，如卡他莫拉菌，则很少见。
