脊髓小胶质细胞 Iba-1 表达的上调在神经病理性疼痛过敏缓解后仍然持续。
Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity.
机构信息
Institute of Neuroscience, Group of Neuropharmacology, Université catholique de Louvain, Avenue Hippocrate B1.54.10, 1200 Brussels, Belgium; Department of Neurology, University of Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany.
出版信息
Neurosci Lett. 2013 Oct 25;554:146-50. doi: 10.1016/j.neulet.2013.08.062. Epub 2013 Sep 8.
Spinal microglial activation plays a major role in the development of neuropathic pain following peripheral nerve injury. We here provide evidence for an elevated expression of the microglial marker Iba-1 in the lumbar dorsal horn ipsilateral to L5 spinal nerve transection that persists for at least 14 weeks, a time at which mechanical hypersensitivity had fully resolved. Iba-1 expression was, however; significantly lower than at 4 weeks. We therefore conclude that microglia remain partly activated beyond the phase of pain hypersensitivity. Thus, the relation between microglial cells and neuropathic pain outcome is subject to change over time after nerve injury.
脊髓小胶质细胞的激活在周围神经损伤后神经病理性疼痛的发展中起着主要作用。我们在这里提供证据表明，在 L5 脊神经横断术的对侧腰椎背角中，小胶质细胞标志物 Iba-1 的表达升高，至少持续 14 周，此时机械性痛觉过敏已完全缓解。然而，Iba-1 的表达明显低于 4 周时。因此，我们得出结论，小胶质细胞在痛觉过敏阶段之后仍部分激活。因此，神经损伤后，小胶质细胞与神经病理性疼痛结果之间的关系随时间而变化。
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