澳大利亚儿童侵袭性脑膜炎球菌病后遗症的临床负担及预测因素
The clinical burden and predictors of sequelae following invasive meningococcal disease in Australian children.
作者信息
Wang Bing, Clarke Michelle, Thomas Natalie, Howell Stuart, Afzali Hossein Haji Ali, Marshall Helen
机构信息
From the *School of Population Health/Paediatrics and Reproductive Health, University of Adelaide; †Vaccinology and Immunology Research Trials Unit (VIRTU), Women's and Children's Hospital; ‡Vaccinology and Immunology Research Trials Unit (VIRTU), Women's and Children's Hospital, North Adelaide; §Data Management & Analysis Centre, Discipline of Public Health, University of Adelaide; ¶Discipline of Public Health, University of Adelaide; and ‖Career Development Fellow, Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia.
出版信息
Pediatr Infect Dis J. 2014 Mar;33(3):316-8. doi: 10.1097/INF.0000000000000043.
Of 109 children admitted to a tertiary paediatric hospital with a diagnosis of invasive meningococcal disease from 2000-2011, 37.6% (n = 41) developed sequelae; for serogroup B, 41.3% developed sequelae. Independent predictors of sequelae included: fever ≥ 39 °C on hospital presentation [odds ratio (OR): 4.5; P = 0.012] and a diagnosis of septicemia with meningitis compared with septicemia alone (OR: 15.5; P < 0.001) and meningitis alone (OR: 7.8; P = 0.002).
在2000年至2011年期间入住一家三级儿科医院、诊断为侵袭性脑膜炎球菌病的109名儿童中，37.6%（n = 41）出现了后遗症；对于B血清群，41.3%出现了后遗症。后遗症的独立预测因素包括：入院时发热≥39°C[比值比（OR）：4.5；P = 0.012]，以及与单纯败血症相比，诊断为败血症合并脑膜炎（OR：15.5；P < 0.001）和与单纯脑膜炎相比（OR：7.8；P = 0.002）。
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