Tracy Jeremiah C, Klement Giannoula Lakka, Scott Andrew R
Department of Otolaryngology, Tufts Medical Center, Boston, MA, United States.
Int J Pediatr Otorhinolaryngol. 2013 Dec;77(12):2071-4. doi: 10.1016/j.ijporl.2013.08.008. Epub 2013 Aug 22.
Congenital infiltrating lipomatosis is a benign yet locally invasive lipomatous tumor. Current treatment involves surgical excision and reconstruction of craniofacial deformity. Invasion of vital structures often makes complete resection problematic and recurrence is common. We present the case of a 15-year-old female patient with extensive congenital infiltrating lipomatosis involving the left face. A broad treatment algorithm was devised involving surgical resection as well as targeted chemotherapy. At 18 month follow-up the patient demonstrated improved facial symmetry without evidence of disease progression. Combining surgical and medical intervention may allow for a synergistic approach to controlling this rare disease.
先天性浸润性脂肪瘤病是一种良性但具有局部侵袭性的脂肪瘤性肿瘤。目前的治疗方法包括手术切除和颅面畸形重建。重要结构的侵犯常常使完全切除成为难题，且复发很常见。我们报告一例15岁女性患者，患有累及左侧面部的广泛性先天性浸润性脂肪瘤病。设计了一种广泛的治疗方案，包括手术切除以及靶向化疗。在18个月的随访中，患者面部对称性改善，且无疾病进展的迹象。联合手术和药物干预可能为控制这种罕见疾病提供一种协同方法。
