Are caudal-type homeobox genes causal for gastro-esophageal reflux disease and Barrett's esophagus?

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作者信息

Laßmann Silke, Werner Martin

机构信息

Department of Pathology, University Medical Center, Freiburg, Germany,

出版信息

Dig Dis Sci. 2014 Jan;59(1):16-8. doi: 10.1007/s10620-013-2861-0.

DOI:10.1007/s10620-013-2861-0

PMID:24052194

Abstract

摘要

相似文献

Are caudal-type homeobox genes causal for gastro-esophageal reflux disease and Barrett's esophagus?

Dig Dis Sci. 2014 Jan;59(1):16-8. doi: 10.1007/s10620-013-2861-0.

Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.尾型同源盒 1 和 2 的单核苷酸多态性与巴雷特食管相关。

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Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.巴雷特食管及巴雷特相关腺癌中CDX2表达增加而PITX1同源框基因表达减少。

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[Expression of transcription factor in Barrett's esophagus].

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Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.酸和胆汁盐诱导的 CDX2 表达在有无 Barrett 食管的食管鳞状细胞中不同。

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Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett's epithelium development.尾相关同源盒基因Cdx1在巴雷特食管上皮发育过程中食管上皮细胞中的作用。

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Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa.CDX2在巴雷特食管上皮和炎症性食管黏膜中的异常表达。

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COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus.COX-2、CDX2和CDC2免疫组化评估巴雷特食管发育异常-癌进展情况。

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Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus.Cdx2 表达及其在巴雷特食管化生-异型增生-癌序列中的启动子甲基化。

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本文引用的文献

Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.尾型同源盒 1 和 2 的单核苷酸多态性与巴雷特食管相关。

Dig Dis Sci. 2014 Jan;59(1):57-63. doi: 10.1007/s10620-013-2804-9. Epub 2013 Aug 6.

Risk factors in the development of esophageal adenocarcinoma.食管腺癌发展的危险因素。

Am J Gastroenterol. 2013 Feb;108(2):200-7. doi: 10.1038/ajg.2012.387. Epub 2012 Dec 18.

Review on the annual cancer risk of Barrett's esophagus in persons with symptoms of gastroesophageal reflux disease.胃食管反流病症状患者 Barrett 食管的年度癌症风险评估。

Anticancer Res. 2012 Dec;32(12):5465-73.

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.MHC 基因座和染色体 16q24.1 上的常见变异与巴雷特食管易感性相关。

Nat Genet. 2012 Oct;44(10):1131-6. doi: 10.1038/ng.2408. Epub 2012 Sep 9.

A clinical risk prediction model for Barrett esophagus. Barrett 食管的临床风险预测模型。

Cancer Prev Res (Phila). 2012 Sep;5(9):1115-23. doi: 10.1158/1940-6207.CAPR-12-0010. Epub 2012 Jul 11.

Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?肠型和微凹窝型异型增生及黏膜内腺癌中 MUC5AC、MUC6、MUC2、CD10 和 CDX-2 的表达差异：这是否表明 Barrett 食管的胃癌和肠型发生途径不同？

Am J Surg Pathol. 2012 Mar;36(3):331-42. doi: 10.1097/PAS.0b013e31823d08d6.

Incidence of adenocarcinoma among patients with Barrett's esophagus.巴雷特食管患者腺癌的发病率。

N Engl J Med. 2011 Oct 13;365(15):1375-83. doi: 10.1056/NEJMoa1103042.

CDX2 and LI-cadherin expression in esophageal mucosa: use of both markers can facilitate the histologic diagnosis of Barrett's esophagus and carcinoma.CDX2和LI-钙黏蛋白在食管黏膜中的表达：同时使用这两种标志物有助于Barrett食管和食管癌的组织学诊断。

Int J Surg Pathol. 2010 Oct;18(5):330-7. doi: 10.1177/1066896910364228. Epub 2010 May 5.

CDX1 is an important molecular mediator of Barrett's metaplasia.CDX1是巴雷特化生的重要分子介质。

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7565-70. doi: 10.1073/pnas.0502031102. Epub 2005 May 13.

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