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分析孕激素受体基因多态性 PROGINS 与卵巢癌风险的关联。

Analyze association of the progesterone receptor gene polymorphism PROGINS with ovarian cancer risk.

机构信息

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, People's Republic of China,

出版信息

Mol Biol Rep. 2013 Oct;40(10):6001-10. doi: 10.1007/s11033-013-2709-x. Epub 2013 Sep 21.

Abstract

Results conflict on the association between progesterone receptor gene (PRG) polymorphism PROGINS and ovarian cancer risk, despite wide-ranging investigations. We therefore performed a meta-analysis of 4,285 ovarian cancer cases and 6,257 controls from 11 published case-control studies. The strength of association between PROGINS polymorphism and ovarian cancer susceptibility was assessed using pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs). The results suggest no significant associations exist between PROGINS polymorphisms and ovarian cancer risk in overall comparisons in all genetic models (T2T2 vs. T1T1: OR = 1.37, 95 % CI = 0.89-2.12, P = 0.15; T1T2 vs. T1T1:OR = 1.09, 95 % CI = 0.88-1.35, P = 0.41; T1T2 + T2T2 vs. T1T1:OR = 1.15, 95 % CI = 0.94-1.40, P = 0.17; T2T2 vs. T1 T1 + T1T2:OR = 1.34, 95 % CI = 0.87-2.07, P = 0.18). In conclusion, the results of this meta-analysis indicate that the PRG polymorphism PROGINS is not associated with ovarian cancer risk when multiple ethnic groups or regions were considered overall.

摘要

结果在孕激素受体基因(PRG)多态性 PROGINS 与卵巢癌风险之间存在冲突,尽管进行了广泛的研究。因此,我们对来自 11 项已发表的病例对照研究的 4285 例卵巢癌病例和 6257 例对照进行了荟萃分析。使用合并优势比(OR)及其相应的 95%置信区间(CI)评估 PROGINS 多态性与卵巢癌易感性之间的关联强度。结果表明,在所有遗传模型的总体比较中,PROGINS 多态性与卵巢癌风险之间没有显著关联(T2T2 与 T1T1:OR = 1.37,95%CI = 0.89-2.12,P = 0.15;T1T2 与 T1T1:OR = 1.09,95%CI = 0.88-1.35,P = 0.41;T1T2 + T2T2 与 T1T1:OR = 1.15,95%CI = 0.94-1.40,P = 0.17;T2T2 与 T1T1 + T1T2:OR = 1.34,95%CI = 0.87-2.07,P = 0.18)。总之,这项荟萃分析的结果表明,当考虑多个种族或地区时,PRG 多态性 PROGINS 与卵巢癌风险无关。

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