Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761-1 Sanggye 7-dong, Nowon-gu, Seoul 139-707, Korea.
J Ultrasound Med. 2013 Oct;32(10):1753-7. doi: 10.7863/ultra.32.10.1753.
We measured the carotid intima-media thickness, a surrogate marker of early atherosclerosis, in patients with carpal tunnel syndrome compared to a control group to evaluate the risk of atherosclerotic disease.
Between January 2011 and December 2011, female patients presenting to the outpatient neurology clinic for pain and paresthesia in the hands were screened for study enrollment. Patients 30 years or older were eligible for the study if they did not have a history of stroke or cardiovascular disease.
During the study period, 111 patients (58 in the carpal tunnel syndrome group and 53 in the control group) were enrolled, with a mean age of 56 years (range, 32-79 years). There were no significant differences in baseline characteristics except maximum carotid intima-media thickness and body mass index. The maximum intima-media thickness was greater in the carpal tunnel syndrome group (mean ± SD, 1.05 ± 0.17 mm) than the control group (0.85 ± 0.22 mm; P < .0001). The body mass index was greater among the controls (P = .012). Simple linear regression analysis revealed that age (P < .0001), carpal tunnel syndrome (P < .0001), hypertension (P = .022), and systolic blood pressure (P = .034) were statistically significantly associated with increased intima-media thickness. Multiple linear regression analysis revealed that hypertension (P = .033), systolic blood pressure (P = .022), age (P < .0001), and carpal tunnel syndrome (P < .0001) were significantly associated with increased intima-media thickness, with carpal tunnel syndrome being the most influential factor (β = 0.489).
The maximum carotid intima-media thickness was significantly increased in patients with carpal tunnel syndrome compared to controls. Chronic inflammation beyond the traditional cardiovascular risk factors might be related to increased carotid intima-media thickness in patients with carpal tunnel syndrome.
我们测量了腕管综合征患者与对照组的颈动脉内膜中层厚度（早期动脉粥样硬化的替代标志物），以评估动脉粥样硬化疾病的风险。
2011 年 1 月至 2011 年 12 月期间，在门诊神经科诊所就诊的手部疼痛和感觉异常的女性患者接受了研究入组筛查。如果患者无中风或心血管疾病病史，且年龄在 30 岁或以上，则有资格参加研究。
在研究期间，共有 111 名患者（腕管综合征组 58 例，对照组 53 例）入组，平均年龄为 56 岁（范围 32-79 岁）。除最大颈动脉内膜中层厚度和体重指数外，两组的基线特征无显著差异。腕管综合征组的最大内膜中层厚度（平均值±标准差，1.05±0.17mm）大于对照组（0.85±0.22mm；P<0.0001）。对照组的体重指数较大（P=0.012）。简单线性回归分析显示，年龄（P<0.0001）、腕管综合征（P<0.0001）、高血压（P=0.022）和收缩压（P=0.034）与内膜中层厚度增加有统计学显著相关性。多元线性回归分析显示，高血压（P=0.033）、收缩压（P=0.022）、年龄（P<0.0001）和腕管综合征（P<0.0001）与内膜中层厚度增加显著相关，其中腕管综合征是最具影响力的因素（β=0.489）。
与对照组相比，腕管综合征患者的颈动脉内膜中层厚度明显增加。除传统心血管危险因素外，慢性炎症可能与腕管综合征患者的颈动脉内膜中层厚度增加有关。
