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使用99mTc-司他米比单光子发射计算机断层扫描(SPECT)进行心肌灌注成像(MPI)时,胃壁放射性示踪剂摄取增加与长期使用奥美拉唑胶囊之间的关联。

The association of increased stomach wall radiotracer uptake with prolonged use of omeprazole capsules on myocardial perfusion imaging (MPI) using 99mTc-sestamibi SPECT.

作者信息

Javadi Hamid, Jallalat Sara, Semnani Shahriar, Mogharrabi Mehdi, Nabipour Iraj, Tabib Seyed Masoud, Abbaszadeh Moloud, Assadi Majid

机构信息

Golestan Research Center of Gastroenterology and Hepatology, (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran.

出版信息

Nucl Med Rev Cent East Eur. 2013;16(2):91-4. doi: 10.5603/NMR.2013.0042.

DOI:10.5603/NMR.2013.0042
PMID:24068640
Abstract

Myocardial perfusion imaging (MPI) is widely used in routine practice for diagnosis and risk stratification of coronary artery disease (CAD). Intense curvilinear activity in the stomach wall of a patient was seen on MPI raw data. This phenomenon was completely dissimilar to the familiar intraluminal gastric reflux of sestamibi. This observed activity could have resulted in false-positive or false-negative artifacts - and inaccurate diagnosis - of the inferior wall of the left ventricle after MPI processing. On further exploration, the current researchers found that the patient had a history of 10-year Omeprazole capsule consumption. The authors present this infrequent case of intense stomach uptake to stress the related clinical and diagnostic implications with the aim to stimulate acute awareness of possible, unexpected infringements on image quality that could potentially interfere with accurate interpretation of the data.

摘要

心肌灌注成像(MPI)在冠状动脉疾病(CAD)的诊断和风险分层的常规实践中被广泛应用。在MPI原始数据上观察到一名患者胃壁出现强烈的曲线状活动。这种现象与常见的锝[99mTc]甲氧基异丁基异腈腔内胃反流完全不同。这种观察到的活动可能会在MPI处理后导致左心室下壁出现假阳性或假阴性伪影,进而造成诊断不准确。经进一步探究,目前的研究人员发现该患者有服用奥美拉唑胶囊10年的病史。作者展示了这种罕见的胃强烈摄取情况,以强调相关的临床和诊断意义,旨在促使人们敏锐地意识到可能出现的、意想不到的对图像质量的影响,这些影响可能会干扰数据的准确解读。

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引用本文的文献

1
What is this image? 2019: Image 2 result : Reduction in interfering gastric wall uptake on myocardial perfusion SPECT following a 2-week period of omeprazole withdrawal.这张图像是什么?2019年:图像2结果:在停用奥美拉唑2周后,心肌灌注单光子发射计算机断层扫描(SPECT)上干扰性胃壁摄取减少。
J Nucl Cardiol. 2019 Oct;26(5):1517-1519. doi: 10.1007/s12350-019-01829-2. Epub 2019 Jul 29.