Aarntzen Erik Hjg, Srinivas Mangala, Schreibelt Gerty, Heerschap Arend, Punt Cornelius Ja, Figdor Carl G, Oyen Wim J, de Vries I Jolanda M
Department of Tumor Immunology; Nijmegen Centre for Molecular Life Sciences; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Nuclear Medicine; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
Oncoimmunology. 2013 Jul 1;2(7):e24661. doi: 10.4161/onci.24661. Epub 2013 Apr 30.
Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
基于树突状细胞（DC）的疫苗需要这些细胞迁移至淋巴结（LN）。然而，不幸的是，DC的迁移率通常非常低。我们研究了提高基于DC的疫苗迁移效率的策略。令人惊讶的是，DC数量的减少而非注射部位的预处理改善了对LN的靶向性。
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