Migaud Henri, Putman Sophie, Combes Antoine, Berton Charles, Bocquet Donatien, Vasseur Laurent, Girard Julien
Department of Orthopedic Surgery, Roger Salengro Hospital, University of Lille, 2 Av Oscar Lambret, 59037 Lille Cedex, France ; Orthopaedics Department, University of Lille, 2 avenue Oscar Lambret, 59037 Lille Cedex, France.
HSS J. 2012 Oct;8(3):262-9. doi: 10.1007/s11420-012-9300-1. Epub 2012 Sep 11.
Recent studies have recommended the discontinuation of metal-on-metal (MoM) components in total hip arthroplasty (THA) because of adverse effects reported with large-diameter MoM THA. This is despite favorable long-term results observed with 28 and 32 mm MoM bearings.
QUESTIONS/PURPOSES: The aim of this study was to assess the value of calls for an end to MoM bearings as THA components. Specifically, we wish to address the risks associated with MoM bearings including adverse soft tissue reactions, metal ion release, and carcinogenic risk.
The study evaluates the arguments in the literature reporting on MoM (adverse soft tissue reactions, metal ion release, and carcinogenic risk) and the experience of the current authors who re-introduced these bearings in 1995. They are balanced by a benefit-risk review of the literature and the authors' experience with MoM use.
Adverse reactions to metallic debris as well as metal ion release are predictable and can be prevented by adequate design (arc of coverage, clearance), metallurgy (forged instead of cast alloy, high-carbide content), and appropriate component orientation. There is no scientific evidence that carcinogenicity is increased in subjects with MoM hip prostheses. MoM articulations appear to be attractive allowing safe hip resurfacing, decreasing the risk of THA revision in active patients, and providing secure THA fixation with cement in cages in severely deformed hips. MoM bearings in women of child-bearing age are controversial, but long-term data on metallic devices in adolescents undergoing spinal surgery seem reassuring.
Adequate selection of MoM articulations ensures their safe use. These articulations are sensitive to orientation. Fifteen years of safe experience with 28- and 32-mm bearings of forged alloy and high-carbide content is the main reason for retaining them in primary and revision THA.
近期研究建议在全髋关节置换术(THA)中停用金属对金属(MoM)组件,原因是大直径MoM全髋关节置换术报告了不良影响。尽管28毫米和32毫米MoM轴承观察到了良好的长期效果,但仍有此建议。
问题/目的:本研究的目的是评估呼吁停止将MoM轴承用作THA组件的价值。具体而言,我们希望探讨与MoM轴承相关的风险,包括不良软组织反应、金属离子释放和致癌风险。
该研究评估了文献中关于MoM(不良软组织反应、金属离子释放和致癌风险)的论点以及当前作者在1995年重新引入这些轴承的经验。通过对文献的利弊审查以及作者使用MoM的经验来进行权衡。
对金属碎屑的不良反应以及金属离子释放是可预测的,并且可以通过适当的设计(覆盖弧、间隙)、冶金(锻造而非铸造合金、高碳化物含量)和合适的组件取向来预防。没有科学证据表明MoM髋关节假体患者的致癌性会增加。MoM关节似乎很有吸引力,可实现安全的髋关节表面置换,降低活跃患者THA翻修的风险,并为严重畸形髋关节的骨水泥固定提供可靠的THA固定。育龄女性使用MoM轴承存在争议,但青少年脊柱手术中金属装置的长期数据似乎令人放心。
对MoM关节进行充分选择可确保其安全使用。这些关节对取向敏感。28毫米和32毫米锻造合金且高碳化物含量的轴承有15年的安全使用经验,这是在初次和翻修THA中保留它们的主要原因。