偏头痛患者头痛和区域性脑血流的评估。
Evaluation of headache and regional cerebral flood flow in patients with migraine.
机构信息
From the *Departments of Nuclear Medicine, †Psychology, and ‡Neurology, Third Hospital Affiliated Sun Yat-sen University, Guangzhou, China.
出版信息
Clin Nucl Med. 2013 Nov;38(11):874-7. doi: 10.1097/RLU.0b013e3182a75927.
PURPOSE OF THE REPORT
The aim of this study is to observe the abnormalities of regional cerebral blood flow (rCBF) in migraine patients and to evaluate its relation to the severity of the headache in patients with migraine.
PATIENTS AND METHODS
The rCBF imaging was done on 19 patients with migraine and 15 normal controls using single-photon emission computed tomography (SPECT). The abnormal character of cerebral perfusion function was analyzed with Statistical Parametric Mapping (SPM) software, and the headache grade of patients was evaluated with the headache severity measuring scale.
RESULTS
The results of SPM analysis demonstrated a decreased rCBF on both sides of the frontal and temporal lobes, left parietal lobe, and right occipital lobe (P < 0.001), and increased rCBF focus on the left prefrontal lobe and right temporal lobe (P < 0.001). The headache scores in migraineurs were correlated to the rCBF on the bilateral temporal lobes and right frontal lobe (P < 0.001).
CONCLUSIONS
The migraineurs had lower rCBF at the frontal and temporal lobes, and the lower rCBF was correlated to the degree of headache.
目的
本研究旨在观察偏头痛患者的局部脑血流（rCBF）异常，并评估其与偏头痛患者头痛严重程度的关系。
方法
采用单光子发射计算机断层扫描（SPECT）对 19 例偏头痛患者和 15 例正常对照者进行 rCBF 成像。采用统计参数图（SPM）软件分析脑灌注功能异常特征，采用头痛严重程度测量量表评估患者头痛程度。
结果
SPM 分析结果显示，偏头痛患者双侧额叶和颞叶、左侧顶叶及右侧枕叶 rCBF 降低（P<0.001），左侧额前叶和右侧颞叶 rCBF 增高（P<0.001）。偏头痛患者的头痛评分与双侧颞叶和右侧额叶 rCBF 呈正相关（P<0.001）。
结论
偏头痛患者额叶和颞叶 rCBF 降低，rCBF 降低与头痛程度相关。
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