Yılmaz Yavuz, Kutman H Gözde Kanmaz, Ulu Hülya Özkan, Canpolat F Emre, Uraş Nurdan, Oğuz S Suna, Dilmen Ugur
Zekai Tahir Burak Maternity Teaching Hospital, Division of Pediatric Surgery , Ankara , Turkey .
J Matern Fetal Neonatal Med. 2014 Aug;27(12):1248-51. doi: 10.3109/14767058.2013.851189. Epub 2013 Nov 7.
Spontaneous intestinal perforation (SIP) is an important surgical emergency in preterm infants.
To evaluate the effect of maternal preeclampsia on development of SIP in premature infants.
Retrospective observational study in a large tertiary neonatal intensive care unit.
The preterm infants of ≤32 weeks of gestational age and birthweight ≤1500 g who were hospitalized were enrolled.
The primary outcome was to determine the association between preeclampsia and SIP.
A total of 22 infants had SIP diagnosis. The incidence of SIP in infants born to preeclamptic mothers (6.2%) was significantly higher compared with those born to normotensive mothers (0.2%). In multinominal logistic regression model, preeclampsia was found to be an independent risk factor of SIP with an odds ratio of 13.5 (95% confidence interval 2.82-65.1).
Maternal preeclampsia seemed to be an independent risk factor for development of SIP in premature infants.
自发性肠穿孔（SIP）是早产儿重要的外科急症。
评估母亲子痫前期对早产儿SIP发生的影响。
在一家大型三级新生儿重症监护病房进行的回顾性观察研究。
纳入孕周≤32周、出生体重≤1500g且住院的早产儿。
主要观察指标是确定子痫前期与SIP之间的关联。
共有22例婴儿被诊断为SIP。子痫前期母亲所生婴儿的SIP发生率（6.2%）显著高于血压正常母亲所生婴儿（0.2%）。在多项逻辑回归模型中，子痫前期被发现是SIP的独立危险因素，比值比为13.5（95%置信区间2.82 - 65.1）。
母亲子痫前期似乎是早产儿发生SIP的独立危险因素。
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