间型霉素对劳氏肉瘤病毒产生的抑制作用。

Inhibition of Rous sarcoma virus production by formycin.

作者信息

Sarih L, Agoutin B, Lecoq O, Weill D, Jullien P, Heyman T

出版信息

Virology. 1985 Aug;145(1):171-5. doi: 10.1016/0042-6822(85)90212-0.

Abstract

The effect of formycin, an adenosine analog, on the growth of chick embryo fibroblasts and on Rous sarcoma virus (RSV) production was studied. An adverse effect on cell proliferation was observed in the presence of 10 microM formycin. Treatment with 5 microM formycin for 24 hr reduced by a factor of about 1000 the yield of infections progeny whereas the cell growth remained unaltered. Moreover the few particles released in the presence of formycin showed a markedly decreased ability to synthesize viral cDNA. This impairment was shown to be related to a nonfunctional primer tRNA.

摘要

研究了腺苷类似物福米韦生对鸡胚成纤维细胞生长和劳氏肉瘤病毒（RSV）产生的影响。在存在10微摩尔福米韦生的情况下，观察到对细胞增殖有不利影响。用5微摩尔福米韦生处理24小时，感染后代的产量降低了约1000倍，而细胞生长保持不变。此外，在福米韦生存在的情况下释放的少量颗粒显示出合成病毒cDNA的能力明显下降。这种损害被证明与无功能的引物tRNA有关。