Shikhman A R, Nikolaeva L V, Kondrakova O A, Dzantiev B B, Blinnikova E I
Zh Mikrobiol Epidemiol Immunobiol. 1985 Apr(4):15-9.
As revealed by double immunodiffusion and the competitive immunoenzyme assay, the immunization of animals with ribosomes isolated from group A streptococci leads to the formation of antibodies to M-protein and does not lead to the formation of antibodies to A-polysaccharide and lipoteichoic acid, which is seemingly caused by the presence of M-protein in ribosomes. Antiribosomal serum has permitted the detection of more antigenic determinants in M-protein than commercial antiserum to homologous M-protein. The immunoenzyme assay for the quantitative determination of ribosomes has been developed.
双向免疫扩散和竞争性免疫酶测定结果表明，用从A组链球菌分离的核糖体免疫动物会导致产生抗M蛋白抗体，而不会产生抗A多糖和脂磷壁酸的抗体，这似乎是由于核糖体中存在M蛋白所致。抗核糖体血清比针对同源M蛋白的商业抗血清能检测到M蛋白中更多的抗原决定簇。已开发出用于核糖体定量测定的免疫酶测定法。
