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鞘内持续注射巴氯芬对严重脑瘫患儿坐位的影响。

The effect of continuous intrathecal baclofen on sitting in children with severe cerebral palsy.

机构信息

Queens Medical Centre, Nottingham University Hospital, Nottingham, UK.

Queens Medical Centre, Nottingham University Hospital, Nottingham, UK.

出版信息

Eur J Paediatr Neurol. 2014 Jan;18(1):45-9. doi: 10.1016/j.ejpn.2013.08.003. Epub 2013 Sep 25.

Abstract

AIM

To investigate the effect of intrathecal baclofen (ITB) on sitting in children with cerebral palsy with severe spasticity; and identify potential sub-groups of patients at particular risk of deterioration.

METHOD

Twenty three children with cerebral palsy, mean age 10 yrs 10 mo were assessed before and after ITB treatment using the Sitting dimension of the Gross Motor Function Measure. Sitting prior to treatment was compared to sitting following ITB treatment in the same children. Exploration of sub groups was also attempted to investigate affects of ITB on sitting according to age and severity of motor impairment.

RESULTS

No significant difference was found in sitting before ITB treatment compared to sitting following insertion of an ITB pump (p = 0.09). No specific age group or classification of motor impairment demonstrated significant deterioration in sitting following ITB treatment.

CONCLUSION

Sitting does not improve or deteriorate in children following treatment with ITB, independent of age or severity of motor impairment.

摘要

目的

研究鞘内注射巴氯芬(ITB)对严重痉挛性脑瘫患儿坐位的影响;并确定有潜在恶化风险的特定患者亚组。

方法

23 名脑瘫患儿,平均年龄 10 岁 10 个月,使用粗大运动功能测量的坐位维度在 ITB 治疗前后进行评估。在同一患儿中,比较治疗前的坐位和 ITB 治疗后的坐位。还尝试了亚组探索,根据年龄和运动损伤严重程度,研究 ITB 对坐位的影响。

结果

与插入 ITB 泵后相比,在 ITB 治疗前的坐位没有显著差异(p = 0.09)。在 ITB 治疗后,没有特定的年龄组或运动损伤分类显示坐位明显恶化。

结论

接受 ITB 治疗后,儿童的坐位不会改善或恶化,与年龄或运动损伤严重程度无关。

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