蛋白激酶 C 同工型在神经肌肉接头处：定位及在神经递质传递和发育中的特定作用。
Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development.
机构信息
Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
出版信息
J Anat. 2014 Jan;224(1):61-73. doi: 10.1111/joa.12106. Epub 2013 Sep 15.
Abstract
The protein kinase C family (PKC) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.
摘要
蛋白激酶 C 家族（PKC）调节多种神经功能，包括神经递质释放。不同细胞和区域中广泛的 PKC 同工型的选择性激活可能有助于 PKC 磷酸化活性的功能多样性。在这篇综述中，我们描述了 PKC 家族在神经肌肉接头处的同工型定位、磷酸化功能、调节和信号转导。数据表明 PKC 家族参与神经肌肉接头的几个重要功能，特别是在突触的成熟和成年期神经传递的调制中。
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本文引用的文献
1
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP.
EMBO J. 2013 May 15;32(10):1365-80. doi: 10.1038/emboj.2013.60. Epub 2013 Mar 19.
2
Blocking p75 (NTR) receptors alters polyinnervationz of neuromuscular synapses during development.
J Neurosci Res. 2011 Sep;89(9):1331-41. doi: 10.1002/jnr.22620. Epub 2011 Jun 14.
3
AKAP signaling complexes in regulation of excitatory synaptic plasticity.
Neuroscientist. 2011 Jun;17(3):321-36. doi: 10.1177/1073858410384740. Epub 2011 Apr 15.
4
Transmitter release in the neuromuscular synapse of the protein kinase C theta-deficient adult mouse.
J Comp Neurol. 2011 Apr 1;519(5):849-55. doi: 10.1002/cne.22551.
5
The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.
J Neurosci. 2010 Dec 8;30(49):16514-22. doi: 10.1523/JNEUROSCI.2676-10.2010.
6
Silent synapses in neuromuscular junction development.
J Neurosci Res. 2011 Jan;89(1):3-12. doi: 10.1002/jnr.22494.
7
Decreased phosphorylation of δ and ε subunits of the acetylcholine receptor coincides with delayed postsynaptic maturation in PKC θ deficient mouse.
Exp Neurol. 2010 Sep;225(1):183-95. doi: 10.1016/j.expneurol.2010.06.014. Epub 2010 Jun 25.
8
Involvement of neurotrophin-3 (NT-3) in the functional elimination of synaptic contacts during neuromuscular development.
Neurosci Lett. 2010 Apr 5;473(2):141-5. doi: 10.1016/j.neulet.2010.02.040. Epub 2010 Feb 21.
9
Involvement of brain-derived neurotrophic factor (BDNF) in the functional elimination of synaptic contacts at polyinnervated neuromuscular synapses during development.
J Neurosci Res. 2010 May 15;88(7):1406-19. doi: 10.1002/jnr.22320.
10
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