淋巴结阳性结肠癌中淋巴结比值预测预后的有效性。
The validity of predicting prognosis by the lymph node ratio in node-positive colon cancer.
机构信息
Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
出版信息
Dig Surg. 2013;30(4-6):368-74. doi: 10.1159/000355444. Epub 2013 Sep 30.
BACKGROUND/AIMS: Because the TNM system disregards the number of lymph nodes dissected and inter-individual differences exist in the number of regional lymph nodes, the lymph node ratio (LNR), which is estimated by dividing the number of metastatic lymph nodes by the number of dissected lymph nodes, has been proposed as a prognostic factor in recent years. The purpose of the present study is to examine the validity of predicting prognosis using the LNR in node-positive colon cancer.
METHODS
Three hundred and eleven patients with lymph node metastases who underwent curative surgery for colon cancer at our department between 1992 and 2005 were enrolled. Univariate and multivariate analyses were performed to evaluate the relationship between clinicopathological factors and prognosis.
RESULTS
Among the patients with ≥12 dissected lymph nodes, differentiation, invasion depth and TNM N category were found to be significant independent prognostic factors. On the other hand, among the patients with ≤11 dissected lymph nodes, differentiation and the LNR were found to be significant independent prognostic factors.
CONCLUSION
Among the patients with ≤11 dissected lymph nodes, LNR was a significant independent prognostic factor.
背景/目的：由于 TNM 系统忽略了切除的淋巴结数量，并且个体之间的区域淋巴结数量存在差异，因此近年来提出了淋巴结比率（LNR），它通过将转移淋巴结的数量除以切除的淋巴结数量来估计，作为一种预后因素。本研究旨在检验 LNR 在淋巴结阳性结肠癌中预测预后的有效性。
方法
我们科室在 1992 年至 2005 年间对 311 例接受根治性手术治疗的淋巴结转移结肠癌患者进行了研究。进行单因素和多因素分析，以评估临床病理因素与预后之间的关系。
结果
在≥12 个淋巴结切除的患者中，分化程度、浸润深度和 TNM N 分期是显著的独立预后因素。另一方面，在≤11 个淋巴结切除的患者中，分化程度和 LNR 是显著的独立预后因素。
结论
在≤11 个淋巴结切除的患者中，LNR 是一个显著的独立预后因素。
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