丙戊酸和苯妥英对癫痫患者血清蛋白和免疫球蛋白的影响。

Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients.

作者信息

Garzón P, González-Cornejo S, Román-Maldonado S, Navarro-Ruiz A

出版信息

Gen Pharmacol. 1985;16(4):411-3. doi: 10.1016/0306-3623(85)90207-1.

Abstract

An evaluation of serum protein and immunoglobulins with regard to valproic acid (VPA) and phenytoin (phen) serum levels was performed in 28 epileptic patients. Serum antiepileptic levels were measured in fasting conditions. All patients were classified into the following groups: A (VPA below 50 micrograms/ml), B (VPA 50-89 micrograms/ml), C (VPA above 89 micrograms/ml), D (VPA 50-89 micrograms/ml and phen below 10 micrograms/ml). Patients of group C showed higher serum protein values than groups A (P less than 0.02), B and D (P less than 0.001). The alpha 2 and beta-globulin fractions were higher in group C than the remaining groups (P less than 0.05). Immunoglobulin A, G and M remained unaltered in all patients.

摘要

对28例癫痫患者的血清蛋白和免疫球蛋白与丙戊酸（VPA）和苯妥英（phen）血清水平进行了评估。在空腹条件下测量血清抗癫痫药物水平。所有患者分为以下几组：A组（VPA低于50微克/毫升）、B组（VPA为50 - 89微克/毫升）、C组（VPA高于89微克/毫升）、D组（VPA为50 - 89微克/毫升且phen低于10微克/毫升）。C组患者的血清蛋白值高于A组（P小于0.02）、B组和D组（P小于0.001）。C组的α2和β球蛋白组分高于其余各组（P小于0.05）。所有患者的免疫球蛋白A、G和M均未改变。