Division of Imaging and Biomechanical Engineering, PET Imaging Centre at St Thomas' Hospital, King's College, London, UK.
Br J Haematol. 2014 Feb;164(3):315-28. doi: 10.1111/bjh.12601. Epub 2013 Oct 17.
Positron Emission Tomography (PET) is a functional imaging technique that, combined with computerized tomography (PET-CT), is increasingly used in lymphoma. Most subtypes accumulate fluorodeoxyglucose (FDG) and the increased sensitivity of PET-CT, especially for extranodal disease, compared to CT, makes PET-CT an attractive staging tool. The availability of a staging PET-CT scan also improves the accuracy of subsequent response assessment. 'Interim' PET-CT can be used to assess early response and end-of-treatment PET-CT assesses remission. Clinical trials are currently seeking to establish whether the predictive value of PET-CT can be successfully used to guide individual treatment to reduce toxicity and/or to improve outcomes. Standardized methods for performing and reporting PET have been developed in the context of trials. The role of PET in transplantation selection is currently evolving, as it appears to be more accurate and prognostic than CT. The role of FDG PET-CT throughout the management course in patients with lymphoma is explored in this review, with areas discussed that may limit the use of PET-CT imaging which clinicians should be familiar with to inform practice.
正电子发射断层扫描（PET）是一种功能成像技术，与计算机断层扫描（PET-CT）结合使用，在淋巴瘤中应用越来越广泛。大多数亚型会积聚氟脱氧葡萄糖（FDG），与 CT 相比，PET-CT 的敏感性更高，特别是对于结外疾病，这使得 PET-CT 成为一种有吸引力的分期工具。分期 PET-CT 扫描的可用性也提高了后续反应评估的准确性。“中期”PET-CT 可用于评估早期反应，而治疗结束时的 PET-CT 则评估缓解情况。临床试验目前正在寻求确定 PET-CT 的预测价值是否可以成功用于指导个体化治疗，以降低毒性和/或改善结果。在临床试验背景下已经制定了用于执行和报告 PET 的标准化方法。在移植选择中，PET 的作用目前正在发展，因为它似乎比 CT 更准确和具有预后意义。本综述探讨了 FDG PET-CT 在淋巴瘤患者整个管理过程中的作用，讨论了可能限制 PET-CT 成像使用的领域，临床医生应该熟悉这些领域，以便为实践提供信息。
