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[眼前节疱疹性疾病的治疗]

[Therapy of herpetic diseases of the anterior eye segment].

作者信息

Sundmacher R

出版信息

Klin Monbl Augenheilkd. 1985 Jun;186(6):421-3. doi: 10.1055/s-2008-1050949.

Abstract

Clinico-virologic investigations and the availability of the new antiviral drug Acyclovir have changed our therapeutic approach to deep herpetic diseases. Treatment of the symptoms alone with steroids should now be avoided. Basic treatment should consist of optimal dosages of Acyclovir. However, additional steroid therapy is still necessary. Significant progress in the treatment of dendritic keratitis is to be expected as soon as high-titer interferon preparations become commercially available. Treatment of dendritic keratitis with a combination of a modern antiviral drug and high-titer interferon will reduce the average time the corneal epithelium takes to heal from the present 6 days to 3 days. While considerable progress has been made in the treatment of herpes, no more than a step in the right direction has been taken with herpes zoster varicellosus virus, owing to its greater resistance to Acyclovir.

摘要

临床病毒学研究以及新型抗病毒药物阿昔洛韦的出现改变了我们对深部疱疹性疾病的治疗方法。现在应避免仅用类固醇治疗症状。基本治疗应包括最佳剂量的阿昔洛韦。然而,额外的类固醇疗法仍然是必要的。一旦高滴度干扰素制剂上市,预计在树枝状角膜炎的治疗方面将取得重大进展。用现代抗病毒药物和高滴度干扰素联合治疗树枝状角膜炎将使角膜上皮愈合的平均时间从目前的6天缩短至3天。虽然在疱疹治疗方面已取得相当大的进展,但对于水痘带状疱疹病毒,由于其对阿昔洛韦的耐药性更强,目前仅朝着正确方向迈出了一小步。

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