韩国非小细胞肺癌中的 RET 融合基因。
RET fusion genes in Korean non-small cell lung cancer.
机构信息
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
出版信息
J Korean Med Sci. 2013 Oct;28(10):1555-8. doi: 10.3346/jkms.2013.28.10.1555. Epub 2013 Sep 25.
Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
最近，在大约 1%的非小细胞肺癌（NSCLC）中发现了重排期间转位（RET）融合。为了了解韩国 NSCLC 中 RET 融合基因的流行情况，我们使用逆转录聚合酶链反应（RT-PCR）检测了 156 例手术切除的 NSCLC 中的 RET 融合基因。鉴定出两个 KIF5B-RET 融合和一个 CCDC6-RET 融合。所有三名患者均为女性，从不吸烟，患有腺癌。RET 融合基因与 EGFR、KRAS 突变和 EML4-ALK 融合互斥。RET 融合基因在韩国接受手术治疗的 NSCLC 患者中占 1.9%（3 例/156 例）。
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