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Comparison of dosiology between three dimensional conformal and intensity-modulated radiotherapies (5 and 7 fields) in gastric cancer post-surgery.

作者信息

Ma Hong, Han Jun, Zhang Tao, Ke Yang

机构信息

Department of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

出版信息

J Huazhong Univ Sci Technolog Med Sci. 2013 Oct;33(5):759-764. doi: 10.1007/s11596-013-1193-9. Epub 2013 Oct 20.


DOI:10.1007/s11596-013-1193-9
PMID:24142733
Abstract

The purpose of this study was to compare the dose distribution of intensity-modulated radiotherapy (IMRT) in 7 and 5 fields as well as 3-D conformal radiotherapy (3D-CRT) plans for gastric cancer using dosimetric analysis. In 15 patients with gastric cancer after D1 resection, dosimetric parameters for IMRT (7 and 5 fields) and 3D-CRT were calculated with a total dose of 45 Gy (1.8 Gy/day). These parameters included the conformal index (CI), homogeneity index (HI), maximum dose spot for the planned target volume (PTV), dose-volume histogram (DVH) and dose distribution in the organs at risk (OAR), mean dose (Dmean), maximal dose (Dmax) in the spinal cord, percentage of the normal liver volume receiving more than 30 Gy (V30) and percentage of the normal kidney volume receiving more than 20 Gy (V20). IMRT (7 and 5 fields) and 3D-CRT achieved the PTV coverage. However, IMRT presented significantly higher CI and HI values and lower maximum dose spot distribution than 3D-CRT (P=0.001). For dose distribution of OAR, IMRT had a significantly lower Dmean and Dmax in spinal cord than 3D-CRT (P=0.009). There was no obvious difference in V30 of liver and V20 of kidney between IMRT and 3D-CRT, but 5-field IMRT showed lower Dmean in the normal liver than other two plans (P=0.001). IMRT revealed favorable tumor coverage as compared to 3D-CRT and IMRT plans. Specifically, 5-field IMRT plan was superior to 3D-CRT in protecting the spinal cord and liver, but this superiority was not observed in the kidney. Further studies are needed to compare differences among the three approaches.

摘要

相似文献

[1]
Comparison of dosiology between three dimensional conformal and intensity-modulated radiotherapies (5 and 7 fields) in gastric cancer post-surgery.

J Huazhong Univ Sci Technolog Med Sci. 2013-10

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[3]
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引用本文的文献

[1]
Adjuvant chemoradiation for gastric carcinoma: State of the art and perspectives.

Clin Transl Radiat Oncol. 2018-3-13

[2]
Dosimetric Comparison of Three Different Radiotherapy Techniques in Antrum-Located Stomach Cancer.

Asian Pac J Cancer Prev. 2017-3-1

[3]
Tomotherapy as an adjuvant treatment for gastroesophageal junction and stomach cancer may reduce bowel and bone marrow toxicity compared to intensity-modulated radiotherapy and volumetric-modulated arc therapy.

Oncotarget. 2017-6-13

[4]
Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy.

Oncol Lett. 2016-7

[5]
Double-arc volumetric modulated therapy improves dose distribution compared to static gantry IMRT and 3D conformal radiotherapy for adjuvant therapy of gastric cancer.

Radiat Oncol. 2015-5-19

本文引用的文献

[1]
Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy.

Radiat Oncol. 2011-6-21

[2]
Intensity-modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation.

Health Technol Assess. 2010-10

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Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer.

Cancer. 2010-8-15

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Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin's lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy.

Int J Radiat Oncol Biol Phys. 2009-11-15

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Radiother Oncol. 2009-8

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N Engl J Med. 2008-7-31

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Cancer Radiother. 2008-3

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Eur J Cancer. 2008-1

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Int J Radiat Oncol Biol Phys. 2007-3-1

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