土耳其稳定型冠状动脉疾病门诊患者静息心率及临床特征分析：脉搏研究

Analysis of resting heart rate and clinical characteristics in outpatients with stable coronary artery disease in Turkey: PULSE study.

作者信息

Ergene Oktay, Akyildiz Zehra Ilke

机构信息

Department of Cardiology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.

出版信息

Cardiol J. 2014;21(4):378-83. doi: 10.5603/CJ.a2013.0151. Epub 2013 Oct 21.

DOI:10.5603/CJ.a2013.0151

PMID:24146273

Abstract

BACKGROUND

An association between resting heart rate (RHR) and cardiovascular morbidity and mortality has been shown in patients with coronary artery disease (CAD). We aimed to evaluate the RHR and its relationship with clinical variables in outpatients with stable CAD at secondary and tertiary care centers in Turkey.

METHODS

Adults with stable CAD in sinus rhythm were included in this non-interventional, national, cross-sectional, multicenter study. Data were collected at a single study visit from 83 centers.

RESULTS

The mean ± standard deviation age of all patients (n = 2,919) was 61 ± 10 years and 73% were males. The mean (SD) RHR was 73 ± 12 bpm, and 62% of patients had RHR of ≥ 70 bpm. Females more frequently had RHR ≥ 70 bpm compared with males (67% vs. 60%; p = 0.002). RHR was significantly higher in patients with angina than in those without (76 ± 13 vs. 73 ± 11 bpm, p < 0.001). Left ventricular ejection fraction and heart rate lower-ing drug use were significantly lower in patients with a RHR ≥ 70 bpm (p < 0.05).

CONCLUSIONS

The RHR of outpatients with stable CAD was not within the level recommended by the guidelines.

摘要

背景

冠状动脉疾病（CAD）患者的静息心率（RHR）与心血管疾病的发病率和死亡率之间存在关联。我们旨在评估土耳其二级和三级医疗中心稳定型CAD门诊患者的RHR及其与临床变量的关系。

方法

本项非干预性、全国性、横断面、多中心研究纳入了窦性心律的稳定型CAD成年患者。数据在83个中心的单次研究访视中收集。

结果

所有患者（n = 2,919）的平均年龄±标准差为61±10岁，73%为男性。平均（SD）RHR为73±12次/分钟，62%的患者RHR≥70次/分钟。与男性相比，女性RHR≥70次/分钟的情况更常见（67%对60%；p = 0.002）。心绞痛患者的RHR显著高于无心绞痛患者（76±13对73±11次/分钟，p < 0.001）。RHR≥70次/分钟的患者左心室射血分数和使用心率降低药物的比例显著更低（p < 0.05）。