蛆分泌物对创伤大鼠血清中炎性细胞因子的影响。
The effects of maggot secretions on the inflammatory cytokines in serum of traumatic rats.
作者信息
Li Xiaorong, Liu Ning, Xia Xiaoyong, Zhang Shaochun, Bai Junlong, Wang Jiangning
机构信息
Central Laboratory, The Luhe Teaching Hospital of the Capital Medical University.
出版信息
Afr J Tradit Complement Altern Med. 2013 May 16;10(4):151-4. doi: 10.4314/ajtcam.v10i4.24. eCollection 2013.
The objective of this study was to analyse the changes of inflammatory cytokines level in traumatic rat serum after maggot secretions intervention. Acute traumatic rats were randomly divided into three groups that included maggot secretions group, negative group, and the control group. TNF-α, IL-6, SOD, LPO levels were measured by radioimmunoassay. The experimental results showed that TNF-α, IL-6, and SOD levels in the model group were significantly increased; LPO level was decreased and showed significant differences. Thus, the content of inflammatory cytokines in acute skin wounds could be reduced by maggot secretions, which play a role in enhancing wound healing.
本研究的目的是分析蛆虫分泌物干预后创伤大鼠血清中炎性细胞因子水平的变化。将急性创伤大鼠随机分为三组，即蛆虫分泌物组、阴性组和对照组。采用放射免疫分析法测定肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、超氧化物歧化酶（SOD）、脂质过氧化物（LPO）水平。实验结果显示，模型组TNF-α、IL-6和SOD水平显著升高；LPO水平降低，差异有统计学意义。因此，蛆虫分泌物可降低急性皮肤创伤中炎性细胞因子的含量，对促进伤口愈合有作用。
Zotero 插件