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胃胃肠道间质瘤:腹腔镜切除术的作用。38例单中心经验。

Gastrointestinal stromal tumors of the stomach: the role of laparoscopic resection. Single-centre experience of 38 cases.

作者信息

Valle Mario, Federici Orietta, Carboni Fabio, Carpano Silvia, Benedetti Michele, Garofalo Alfredo

机构信息

Department of Digestive Surgery, Regina Elena National Cancer Institute, Via E. Chianesi, 53, 00144, Rome, Italy,

出版信息

Surg Endosc. 2014 Mar;28(3):1040-7. doi: 10.1007/s00464-013-3255-2. Epub 2013 Oct 23.

Abstract

INTRODUCTION

Laparoscopic resection is considered the gold standard of treatment only for small gastric gastrointestinal stromal tumor (GIST).

MATERIALS AND METHODS

Between January 2004 and September 2012, 38 consecutive gastric GISTs were operated on by laparoscopic approach, without conversions. Thirty-five cases were primary GISTs and three were bleeding GISTs with hepatic metastases non-responding to conservative therapy treated by emergency surgery.

RESULTS

Median tumor size was 3.63 cm (1.8-17 cm). In two cases tumor size was <2 cm, between 2 and 5 cm in 26 cases, between 5 and 10 cm in eight cases, and >10 cm in two cases. In two cases, localization was in the cardia, fundus in ten cases, lesser curve in 11 cases, greater curve in 12 cases, and antrum in three cases. We performed 24 wedge resections, eight transgastric resections and six antrectomies. An Endo-GIA™ was used in 25 cases, and a manual laparoscopic reconstruction with extramucosal suture was performed in 13 cases. No postoperative mortality and morbidity was observed. The routine use of laparoscopy allowed us to perform resections in 100 % of cases, even in those where preoperative imaging suggested an open approach according to the current guidelines.

CONCLUSIONS

The use of a pre-resection endobag avoids spillage and seeding, thus increasing the possibility of resection. In conclusion, we consider the laparoscopic approach as mandatory in all cases, always considering the possibility of converting to the open technique when necessary.

摘要

引言

腹腔镜切除术仅被视为治疗小胃胃肠道间质瘤(GIST)的金标准。

材料与方法

2004年1月至2012年9月期间,连续38例胃GIST患者接受了腹腔镜手术,无一例中转开腹。35例为原发性GIST,3例为出血性GIST伴肝转移,经保守治疗无效后行急诊手术。

结果

肿瘤中位大小为3.63 cm(1.8 - 17 cm)。2例肿瘤大小<2 cm,26例在2至5 cm之间,8例在5至10 cm之间,2例>10 cm。2例位于贲门,10例位于胃底,11例位于胃小弯,12例位于胃大弯,3例位于胃窦。我们进行了24例楔形切除术、8例经胃切除术和6例胃窦切除术。25例使用了Endo - GIA™,13例进行了腹腔镜手工黏膜外缝合重建。未观察到术后死亡率和发病率。腹腔镜的常规使用使我们能够在100%的病例中进行切除,即使在那些术前影像学检查根据当前指南提示需开腹手术的病例中也是如此。

结论

术前使用内袋可避免肿瘤播散,从而增加切除的可能性。总之,我们认为在所有病例中腹腔镜手术都是必要的,同时始终考虑在必要时中转开腹手术的可能性。

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