Nestle U, Guckenberger M
Klinik für Strahlenheilkunde, Universitätsklinikum Freiburg, Deutschland.
Zentralbl Chir. 2013 Oct;138 Suppl 1:S25-31. doi: 10.1055/s-0033-1350866. Epub 2013 Oct 22.
Stereotactic body radiotherapy (SBRT) is a method for the highly precise application of percutaneous high dose radiotherapy of extracranial targets in a limited number of treatment fractions. Due to the excellent local control rates, SBRT is now well established in limited stage lung tumours. In medically inoperable patients SBRT is the method of choice, in high-risk patients and patients who refuse resection, the current literature recommends SBRT as a reasonable therapeutic option. An analysis of the SBRT working group of the German Society for Radiation Oncology showed that the treatment results in Germany are well comparable to international data. The limitations of SBRT lie in the treatment of tumours in the direct neighbourhood of so-called "serial" normal tissues, which is due to the risk of severe late effects of high dose radiation. Therefore these patients should be treated by SBRT, if at all, in the context of respective clinical studies.
立体定向体部放射治疗(SBRT)是一种在有限次数的治疗分割中对颅外靶区进行经皮高剂量放射治疗的高精度方法。由于其出色的局部控制率,SBRT目前在局限性期肺癌中已得到广泛应用。在医学上无法手术的患者中,SBRT是首选方法;在高危患者和拒绝手术切除的患者中,当前文献推荐SBRT作为一种合理的治疗选择。德国放射肿瘤学会SBRT工作组的一项分析表明,德国的治疗结果与国际数据具有良好的可比性。SBRT的局限性在于治疗所谓“串联”正常组织附近的肿瘤,这是由于高剂量辐射存在严重迟发效应的风险。因此,这些患者若要接受SBRT治疗,应在相应的临床研究背景下进行。