Tran Lan Anh T, Yoshida Lay Myint, Nakagomi Toyoko, Gauchan Punita, Ariyoshi Koya, Anh Dang Duc, Nakagomi Osamu, Thiem Vu Dinh
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan ; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Trop Med Health. 2013 Sep;41(3):121-7. doi: 10.2149/tmh.2013-09. Epub 2013 Aug 20.
Rotavirus is a leading cause of severe diarrhea among children worldwide. Thus, the World Health Organization recommended including rotavirus vaccines in national immunization programs. One concern about rotavirus vaccine, however, is a possible association with intussusception. Thus, it is crucial to know the baseline incidence of intussusception in the first year of life. A study conducted in Hanoi, Vietnam showed that the incidence of intussusception was the highest in the world. This retrospective cross-sectional study was undertaken to determine the incidence of intussusception among children <5 years of age in Nha Trang, Vietnam. Hospital charts between 2009 and 2011 were reviewed in Khanh Hoa Provincial General Hospital where virtually all cases of intussusception occurring in the city were assumed to have been encountered. The incidence of intussusception among children <1 year of age was 296 per 100,000 person-years (95% confidence interval [CI]: 225-382), and that among children <5 years of age was 196 per 100,000 person-years (95% CI: 169-226), confirming the high incidence of intussusception in Vietnam. Nevertheless, there was no intussusception in the first three months of life. We therefore recommend that the first dose of any rotavirus vaccine be administered to infants between 6 and 12 weeks of age.
轮状病毒是全球儿童严重腹泻的主要病因。因此，世界卫生组织建议将轮状病毒疫苗纳入国家免疫规划。然而，对轮状病毒疫苗的一个担忧是它可能与肠套叠有关。因此，了解生命第一年肠套叠的基线发病率至关重要。在越南河内进行的一项研究表明，肠套叠的发病率是世界上最高的。这项回顾性横断面研究旨在确定越南芽庄市5岁以下儿童肠套叠的发病率。对庆和省综合医院2009年至2011年期间的医院病历进行了审查，该市几乎所有发生的肠套叠病例都被认为在此处有记录。1岁以下儿童肠套叠的发病率为每10万人年296例（95%置信区间[CI]：225 - 382），5岁以下儿童的发病率为每10万人年196例（95%CI：169 - 226），证实了越南肠套叠的高发病率。然而，在生命的前三个月没有肠套叠病例。因此，我们建议在婴儿6至12周龄时接种第一剂任何轮状病毒疫苗。
