抑制Aβ聚集的基于γ-氨基酸肽的小分子配体。
γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation.
作者信息
Wu Haifan, Li Yaqiong, Bai Ge, Niu Youhong, Qiao Qiao, Tipton Jeremiah D, Cao Chuanhai, Cai Jianfeng
机构信息
Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
出版信息
Chem Commun (Camb). 2014 May 25;50(40):5206-8. doi: 10.1039/c3cc46685j. Epub 2013 Oct 25.
PMID:24158240
Abstract
We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.
摘要
我们报道了一类新型γ-氨基酸肽单珠单化合物（OBOC）文库的设计、合成、表征及评估，从中鉴定出一种小的γ-氨基酸肽可有效预防和拆解Aβ聚集。
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