角膜缘干细胞保存的板层角膜移植术治疗进展期圆锥角膜。

Limbal stem cell-sparing lamellar keratoplasty for the management of advanced keratoglobus.

机构信息

*Cornea and External Disease Service, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and †Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Cornea. 2014 Jan;33(1):105-8. doi: 10.1097/ICO.0b013e3182a9b1ac.

DOI:10.1097/ICO.0b013e3182a9b1ac

PMID:24162750

Abstract

PURPOSE

To describe the technique and outcomes of limbal stem cell-sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB).

METHODS

In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patients had isolated KGB, 2 were affected with the Ehlers-Danlos syndrome, and the other subject had osteogenesis imperfecta. Epithelial healing, anatomical results (corneal thickness and keratometry), and visual outcomes were evaluated after this intervention.

RESULTS

Three of the 6 patients were male. Complete epithelial healing occurred in 7 eyes during 2 weeks. Refractory persistent epithelial defect and graft melting occurred in 1 eye. Corneal thickness increased and central keratometry decreased after the LSCS-LKP was performed in all the patients. The patients were followed up for at least 6 months. Visual acuity improved in all eyes except 1.

CONCLUSIONS

LSCS-LKP is an effective procedure for preserving ocular integrity and for improving visual acuity in patients with advanced KGB. Early surgical intervention can be considered before the occurrence of vision-threatening traumatic corneal rupture.

摘要

目的

描述边缘干细胞保存性板层角膜移植术（LSCS-LKP）治疗进展性球形角膜（KGB）的技术和结果。

方法

在 2010 年 3 月至 2012 年 12 月期间，我们进行了一项连续的介入性病例系列研究，对 6 名患者的 8 只眼进行了 LSCS-LKP。其中 3 例为孤立性 KGB，2 例为埃勒斯-当洛斯综合征患者，另 1 例为成骨不全症患者。对该干预措施后的上皮愈合、解剖学结果（角膜厚度和角膜曲率计）和视力结果进行了评估。