半侧巨脑回畸形：锝-99m-乙基半胱氨酸二聚体脑灌注单光子发射计算机断层扫描中半侧灌注不足的罕见原因。

Hemimegalencephaly: A rare cause of hemihypoperfusion on 99m technetium-ethyl cysteinate dimer brain perfusion single-photon emission computed tomography.

作者信息

Damle Nishikant A, Singhal Abhinav, Mukherjee Anirban, Sahoo Manas Kumar, Tripathi Madhavi, Bal Chandrasekhar

机构信息

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Nucl Med. 2013 Apr;28(2):93-5. doi: 10.4103/0972-3919.118257.

DOI:10.4103/0972-3919.118257

PMID:24163513

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3800318/

Abstract

Hemimegalencephaly is a rare congenital neuronal migration disorder that can presents with the equally rare finding of hemihypoperfusion on brain perfusion single-photon emission computed tomography (SPECT). It is an extremely rare cause of intractable epilepsy. Technetium-99m ethyl cysteinate dimer (ECD) brain perfusion SPECT is useful in excluding other foci of hypoperfusion in the contralateral since hemispherectomy has been suggested to be the treatment of choice. Furthermore, hemimegalencephaly may present with hyper as well as hypoperfusion on ECD SPECT. We present the case of an 11-year-old male child with intractable seizures who showed hemihypoperfusion in the hemimegalecephalic hemisphere.

摘要

半侧巨脑症是一种罕见的先天性神经元迁移障碍，在脑灌注单光子发射计算机断层扫描（SPECT）上可表现为同样罕见的半侧灌注不足。它是难治性癫痫极其罕见的病因。锝-99m 乙半胱氨酸二聚体（ECD）脑灌注 SPECT 有助于排除对侧其他灌注不足灶，因为半球切除术被认为是首选治疗方法。此外，半侧巨脑症在 ECD SPECT 上可能表现为灌注增强以及灌注不足。我们报告一例 11 岁男性儿童难治性癫痫病例，该患儿在半侧巨脑症半球显示半侧灌注不足。