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单相机偏振敏感全场光相干断层扫描与偏振开关。

Single-camera polarization-sensitive full-field optical coherence tomography with polarization switch.

机构信息

Gwangju Institute of Science and Technology, School of Information and Communications, 261 Cheomdan-gwagiro, Buk-gu, Gwangju 500-712, Republic of Korea.

出版信息

J Biomed Opt. 2013 Oct;18(10):100504. doi: 10.1117/1.JBO.18.10.100504.

Abstract

We present a single-channel detection-based polarization-sensitive full-field optical coherence tomography (PS-FF-OCT) for simultaneous acquisition of high-resolution OCT and linear retardance images. A linearly polarized sub-10-fs laser was used as a broadband light source for the OCT system. A bi-stable polarization switching device, composed of a ferroelectric liquid crystal cell and an analyzer, was employed to get the horizontal and the vertical polarization components of a full-field interference signal. The time-switched two perpendicular interference signals were sequentially recorded by a single charge-coupled device camera, then processed to extract en-face functional images of a biological sample. The rat tail tendon was imaged ex vivo to confirm the imaging feasibility of the proposed system, which showed axial and transverse resolutions of 2 and 1.3 μm, respectively.

摘要

我们提出了一种基于单通道检测的偏振敏感全场光相干断层扫描(PS-FF-OCT)系统,用于同时获取高分辨率 OCT 和线性延迟图像。该 OCT 系统使用线偏振的亚 10fs 激光作为宽带光源。采用由铁电液晶盒和检偏器组成的双稳偏振态快速切换装置,获取全场干涉信号的水平和垂直偏振分量。通过单个电荷耦合器件相机顺序记录时间切换的两个相互垂直的干涉信号,然后进行处理,以提取生物样本的面内功能图像。对大鼠尾腱进行离体成像,以验证所提出系统的成像可行性,结果显示轴向和横向分辨率分别为 2μm 和 1.3μm。

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