CD137 作为肿瘤反应性 T 细胞的生物标志物：在沙漠中觅得黄金。
CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert.
机构信息
Authors' Affiliations: Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.
出版信息
Clin Cancer Res. 2014 Jan 1;20(1):3-5. doi: 10.1158/1078-0432.CCR-13-2573. Epub 2013 Oct 28.
Abstract
Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor.
摘要
尽管人类癌症周围通常有免疫细胞，但只有少数是能识别肿瘤抗原并能消除癌细胞的肿瘤反应性 T 细胞。Ye 及其同事现在发现，这些肿瘤反应性 T 细胞中有许多被标记为表达 CD137，这是一种 T 细胞共刺激受体。
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