年龄可预测接受rt-PA治疗的急性卒中患者的功能结局。
Age Predicts Functional Outcome in Acute Stroke Patients with rt-PA Treatment.
作者信息
Chindaprasirt Jarin, Sawanyawisuth Kittisak, Chattakul Paiboon, Limpawattana Panita, Tiamkao Somsak, Aountri Patcharin, Chotmongkol Verajit
机构信息
Department of Medicine, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Road, Khon Kaen 40002, Thailand.
出版信息
ISRN Neurol. 2013 Sep 19;2013:710681. doi: 10.1155/2013/710681. eCollection 2013.
The standard treatment for acute ischemic stroke is thrombolytic therapy. There is limited data on prognostic factors of acute stroke with thrombolytic therapy particularly in Asian population. Acute ischemic stroke patients who were treated with thrombolytic therapy at Srinagarind Hospital between May 2008 and July 2010 were included. Factors associated with Barthel index more than 80 were studied by multiple logistic regression analysis. There were 75 patients included in the study. The mean NIHSS scores before treatment and at 3 months were 9.16 ± 4.82 and 3.83 ± 4.00, respectively, and median Barthel index at 3 months was 86. Only significant predictor for having Barthel index more than 80 points at 3 months was age (adjusted odds ratio 0.929, 95% confidence interval 0.874, 0.988). Four patients developed intracranial hemorrhage after the treatment (5%), and two died (2.6%). In conclusion, age predicts Barthel index in acute stroke patients with rt-PA treatment.
急性缺血性卒中的标准治疗方法是溶栓治疗。关于接受溶栓治疗的急性卒中预后因素的数据有限，尤其是在亚洲人群中。纳入了2008年5月至2010年7月期间在诗里拉吉医院接受溶栓治疗的急性缺血性卒中患者。通过多因素逻辑回归分析研究与巴氏指数大于80相关的因素。该研究共纳入75例患者。治疗前及3个月时的美国国立卫生研究院卒中量表（NIHSS）平均评分分别为9.16±4.82和3.83±4.00，3个月时巴氏指数中位数为86。3个月时巴氏指数大于80分的唯一显著预测因素是年龄（校正比值比0.929，95%置信区间0.874，0.988）。4例患者治疗后发生颅内出血（5%），2例死亡（2.6%）。总之，年龄可预测接受rt-PA治疗的急性卒中患者的巴氏指数。
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