斯帕替德：无法拮抗蛙皮素诱导的犬胃泌素分泌刺激。

Spantide: failure to antagonize bombesin-induced stimulation of gastrin secretion in dogs.

作者信息

Pappas T, Hamel D, Debas H, Walsh J, Tache Y

出版信息

Peptides. 1985 Sep-Oct;6(5):1001-3. doi: 10.1016/0196-9781(85)90335-3.

Abstract

Spantide ([d-Arg1, d-Trp7,9, Leu11] substance P) was shown to function not only as a substance P receptor antagonist but also as a bombesin receptor antagonist. This study examined the effects of spantide on intravenous bombesin-induced stimulation of gastrin and acid secretion. Dogs were infused with spantide (1 or 10 nmol kg 1 hr 1) or saline and bombesin (60 pmol kg-1 hr-1), and the gastric acid and plasma gastrin responses were monitored. Spantide did not significantly modify gastrin or gastric acid secretion induced by bombesin. It is concluded that spantide may not be a useful bombesin antagonist for in vivo studies.

摘要

七肽蛙皮素（[d-精氨酸1，d-色氨酸7,9，亮氨酸11]P物质）不仅被证明是一种P物质受体拮抗剂，还是一种蛙皮素受体拮抗剂。本研究检测了七肽蛙皮素对静脉注射蛙皮素诱导的胃泌素和胃酸分泌刺激作用的影响。给犬输注七肽蛙皮素（1或10 nmol·kg⁻¹·hr⁻¹）或生理盐水以及蛙皮素（60 pmol·kg⁻¹·hr⁻¹），并监测胃酸和血浆胃泌素反应。七肽蛙皮素并未显著改变蛙皮素诱导的胃泌素或胃酸分泌。得出的结论是，七肽蛙皮素可能不是体内研究中有用的蛙皮素拮抗剂。