神经兴奋氨基酸：4-亚甲基谷氨酸衍生物：简短交流。
Neuroexcitatory amino acids: 4-methylene glutamic acid derivatives : Short Communication.
机构信息
URA 468, CNRS, Université Montpellier II, F-34095, Montpellier Cédex 5, France.
出版信息
Amino Acids. 1995 Dec;9(4):391-5. doi: 10.1007/BF00807276.
PMID:24178887
Abstract
A short synthesis of 4-methylene glutamic acid was achieved. Under thermal conditions the corresponding anhydride reacted with 2,3 dimethylbutadiene to afford the corresponding DIELS-ALDER adduct in good yield. L-4-methylene glutamic acid essentially acts on glutamate metabotropic receptors and is as potent as L-Glu in producing IPs.
摘要
4-亚甲基谷氨酸的短合成。在热条件下，相应的酸酐与 2,3-二甲基丁二烯反应，以良好的收率得到相应的 Diels-Alder 加合物。L-4-亚甲基谷氨酸基本上作用于谷氨酸代谢型受体，其产生 IPs 的效力与 L-Glu 相当。
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