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益生菌在克罗恩病和溃疡性结肠炎治疗中的应用

Probiotics in the management of Crohn's disease and ulcerative colitis.

作者信息

Müllner Katalin, Miheller Pál, Herszényi László, Tulassay Zsolt

机构信息

Semmelweis University, 2nd Department of Internal Medicine, H-1088, Budapest, Szentkirályi u. 46., Hungary.

出版信息

Curr Pharm Des. 2014;20(28):4556-60. doi: 10.2174/13816128113196660727.

Abstract

Probiotics are nowadays frequently used by patients with inflammatory bowel disease, however literature data are conflicting related to their importance. In mild to moderate ulcerative colitis probiotics can be used effectively in induction and maintaining remission, and prevention of pouchitis. As the other side of the shield, there is not sufficient evidence to support the use of probiotics in daily clinical practice in Crohn's disease. The aim of the present review is to provide help for clinicians about the probiotic use in patients with inflammatory bowel disease. The comparison of literature data is limited by the large number of probiotic strains, various combined preparations, and different doses applied in the clinical studies. Small number of comparable protocols and lack of standardization encumber the analysis of study results.

摘要

如今,炎症性肠病患者经常使用益生菌,然而,关于其重要性的文献数据相互矛盾。在轻度至中度溃疡性结肠炎中,益生菌可有效用于诱导和维持缓解以及预防袋炎。另一方面,没有足够的证据支持在克罗恩病的日常临床实践中使用益生菌。本综述的目的是为临床医生在炎症性肠病患者中使用益生菌提供帮助。文献数据的比较受到临床研究中大量益生菌菌株、各种联合制剂和不同剂量应用的限制。可比方案数量少且缺乏标准化阻碍了研究结果的分析。

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