用于靶向癌症治疗的多功能角鲨烯基前药纳米颗粒。
Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy.
作者信息
Bui Duc Trung, Nicolas Julien, Maksimenko Andrei, Desmaële Didier, Couvreur Patrick
机构信息
Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry Cedex, France.
出版信息
Chem Commun (Camb). 2014 May 25;50(40):5336-8. doi: 10.1039/c3cc47427e. Epub 2013 Nov 4.
PMID:24185552
Abstract
Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.
摘要
已制备出具有高药物负载量的荧光和生物素化角鲨烯-吉西他滨前药纳米颗粒，并成功用于靶向不同癌细胞系，导致细胞摄取增加且抗癌效率提高，这代表了源自角鲨烯酰化方法的首个靶向系统。
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