Faculty of Infectious and Tropical Diseases, Department of Immunity and Infection, London School of Hygiene & Tropical Medicine, London, UK; Division of Infection & Immunity, University College London Medical School, London, UK.
Parasite Immunol. 2014 Mar;36(3):131-9. doi: 10.1111/pim.12086.
A good understanding of the immunological correlates of protective immunity is an important requirement for the development of effective vaccines against malaria. However, this concern has received little attention even in the face of two decades of intensive vaccine research. Here, we review the immune response to blood-stage malaria, with a particular focus on the type of vaccine most likely to induce the kind of response required to give strong protection against infection.
对保护性免疫的免疫学相关性有很好的理解,是开发有效疟疾疫苗的重要要求。然而,即使在二十年的密集疫苗研究面前,这一关注点也几乎没有得到关注。在此,我们回顾了对血液期疟疾的免疫反应,特别关注最有可能诱导出对感染提供强大保护所需的那种反应的疫苗类型。
Parasite Immunol. 2014-3
Am J Trop Med Hyg. 1994
Trends Parasitol. 2011-3-23
Expert Rev Vaccines. 2018-2-9
Vaccines (Basel). 2021-9-24
Trop Dis Travel Med Vaccines. 2017-6-6
Cold Spring Harb Perspect Med. 2018-1-2
Hum Vaccin Immunother. 2016-3-3