非周期性乳腺疼痛的绝经前女性的乳腺癌风险估计及筛查结果

Estimated breast cancer risk and screening outcomes among premenopausal women with non-cyclic mastalgia.

作者信息

Rogulski Lech, Bińczyk Jan

机构信息

Medyk-Centrum Private Medical Center, Gynecology and Breast Diseases Clinic, Czestochowa, Poland.

出版信息

Ginekol Pol. 2013 Sep;84(9):754-7. doi: 10.17772/gp/1635.

DOI:10.17772/gp/1635

PMID:24191512

Abstract

OBJECTIVES

Breast pain is a common but worrisome symptom, which can cause a significant psychological burden of cancer stress. It is not known whether breast cancer risk estimation models can be used as an adjunct to the clinical and radiological assessment in counseling women with mastalgia. The aim of our study was to compare the estimated breast cancer risk and screening outcomes between patients with mastalgia and women requesting prophylactic examinations.

MATERIAL AND METHODS

112 premenopausal women with non-cyclic breast pain and 182 control women who presented for prophylactic examination were screened with mammography and ultrasound. Breast cancer risk estimated with the Gail and Tyrer-Cuzick models along with screening outcomes were compared between the groups.

RESULTS

Premenopausal patients with mastalgia had lower estimated breast cancer risk than controls. The difference was observed with both the Gail and Tyrer-Cuzick models (Gail 5-year risk: 0.66 +/- 0.4% vs. 0.77 +/- 0.4%, p=0.0002; Tyrer-Cuzick 5-year risk: 0.85 +/- 0.4% vs. 0.95 +/- 0.3%, p=0.002; Gail lifetime risk: 8.98 +/- 3.6% vs. 9.6 +/- 3.9%, p=0.015; Tyrer-Cuzick lifetime risk: 8.3 +/- 3.1 % vs. 8.9 +/- 2.7 %, p=0.045). Radiological and clinical outcomes were comparable between the groups.

CONCLUSIONS

Breast pain was associated with lower estimated breast cancer risk but had no effect on screening outcomes in the study population.

摘要

目的

乳房疼痛是一种常见但令人担忧的症状，可导致显著的癌症应激心理负担。目前尚不清楚乳腺癌风险评估模型是否可作为临床和放射学评估的辅助手段，用于为患有乳房疼痛的女性提供咨询。我们研究的目的是比较乳房疼痛患者与要求进行预防性检查的女性之间的估计乳腺癌风险和筛查结果。

材料与方法

对112名患有非周期性乳房疼痛的绝经前女性和182名前来进行预防性检查的对照女性进行了乳房X线摄影和超声检查。比较了两组使用Gail模型和Tyrer-Cuzick模型估计的乳腺癌风险以及筛查结果。

结果

绝经前乳房疼痛患者的估计乳腺癌风险低于对照组。Gail模型和Tyrer-Cuzick模型均观察到这种差异（Gail 5年风险：0.66±0.4%对0.77±0.4%，p=0.0002；Tyrer-Cuzick 5年风险：0.85±0.4%对0.95±0.3%，p=0.002；Gail终身风险：8.98±3.6%对9.6±3.9%，p=0.015；Tyrer-Cuzick终身风险：8.3±3.1%对8.9±2.7%，p=0.045）。两组的放射学和临床结果具有可比性。