多奈哌齐对阿尔茨海默病的疗效可以通过计算机模拟的人类 Morris 水迷宫来衡量。
Effect of donepezil in Alzheimer disease can be measured by a computerized human analog of the Morris water maze.
机构信息
International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
出版信息
Neurodegener Dis. 2014;13(2-3):192-6. doi: 10.1159/000355517. Epub 2013 Oct 30.
BACKGROUND
Drug development for Alzheimer disease (AD) is challenged by the success in animal models tested in the Morris water maze (MWM) and the subsequent failures to meet primary outcome measures in phase II or III clinical trials in patients. The human variant of MWM (hMWM) enables us to examine allocentric and egocentric navigation as in the MWM.
OBJECTIVE
It was the aim of this study to examine the utility of a computerized hMWM to assess the effects of donepezil in mild AD.
METHODS
Donepezil 5 mg/day was started after initial hMWM testing in the treated group (n = 12), and after 28 days, the dose was increased to 10 mg/day. The performance after 3 months was compared to that of a non-treated group (n = 12).
RESULTS
Donepezil stabilized or improved the spatial navigation performance after 3 months, especially in the allocentric delayed recall subtask (p = 0.014).
CONCLUSIONS
The computerized hMWM has the potential to measure the effects of donepezil in mild AD. It is a sensitive cognitive outcome measure in AD clinical trials.
背景
阿尔茨海默病（AD）的药物研发受到了挑战，因为在 Morris 水迷宫（MWM）中进行的动物模型测试取得了成功，而随后在 II 期或 III 期临床试验中未能达到主要终点。人类版 MWM（hMWM）使我们能够检查与 MWM 中的环境导航和自我中心导航相关的认知能力。
目的
本研究旨在探讨计算机化 hMWM 在评估多奈哌齐对轻度 AD 患者的疗效中的作用。
方法
在治疗组（n = 12）进行初始 hMWM 测试后开始给予多奈哌齐 5 mg/天，28 天后剂量增加至 10 mg/天。3 个月后的表现与未治疗组（n = 12）进行比较。
结果
多奈哌齐治疗 3 个月后稳定或改善了空间导航表现，尤其是在环境延迟回忆子任务中（p = 0.014）。
结论
计算机化 hMWM 具有测量多奈哌齐对轻度 AD 患者疗效的潜力。它是 AD 临床试验中一种敏感的认知终点测量方法。
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